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Recruiting NCT06743802

The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery

Phase IV Interventional Postoperative Pain

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Coenzyme Q10, Placebo.
Who it may be relevant to
Registry conditions: Postoperative Pain. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Effect of Coenzyme Q10 in Preventing Pain After Thoracoscopic Surgery: a Randomized Controlled Trial

Overview

This study aimed to assess the effectiveness of Coenzyme Q10 in preventing both acute and chronic pain following thoracoscopic surgery, with a focus on its potential benefits in reducing the incidence and severity of pain.

Interventions

  • Drug Coenzyme Q10
    Coenzyme Q10 was administered from admission to one month after discharge at a dose of 200 mg per day (200 mg/qd).
  • Other Placebo
    The placebo was administered from hospital admission until one month after discharge.

Primary outcome measures

  • The incidence of chronic postsurgical pain [Time frame: from the end of surgery to 3 months after surgery]
Secondary outcome measures (10)
  • The incidence of acute postoperative pain with a score ≥4 [Time frame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.]
  • The severity of acute postoperative pain [Time frame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.]
  • The severity of chronic postsurgical pain [Time frame: from the end of surgery to 3 months after surgery]
  • The incidence of neuropathic pain [Time frame: from the end of surgery to 3 months after surgery]
  • The frequency of postoperative rescue analgesic use [Time frame: from the end of surgery to 6 hours,12 hours, 24 hours , 48 hours and 72 hours after surgery.]
  • The dose of analgesic use [Time frame: from the end of surgery to 6 hours,12 hours, 24 hours and 48 hours after surgery.]
  • The quality of recovery score at 3 days Postoperatively [Time frame: from the end of surgery to 3 days.]
  • Health related quality of life score at 3 months Postoperatively [Time frame: from the end of surgery to 3 months after surgery.]
  • Postoperative length of hospital stay [Time frame: from end of surgery to about 3 to 7 days after surgery.]
  • The incidence of adverse reactions [Time frame: From admission to 3 month post-discharge]

Eligibility criteria

Inclusion criteria

  • Aged 18-75 years;
  • American Society of Anesthesiology (ASA) physical status classification I-III;
  • Scheduled for elective lung resection surgery under thoracoscopy;
  • Voluntarily opting for patient-controlled intravenous analgesia;
  • Willing to participate in this trial after consultation with the patient or their family and signing the informed consent form.

Exclusion criteria

  • History of previous thoracotomy or thoracoscopic surgery;
  • Patients converted to open thoracotomy intraoperatively;
  • Severe hepatic or renal dysfunction;
  • History of substance abuse;
  • Pregnancy or breastfeeding;
  • History of chronic pain;
  • Use of coenzyme Q10 for more than one month;
  • Allergy to coenzyme Q10;
  • Patients unable to communicate or cooperate.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Triple blind
Primary purpose
Prevention

Study locations

China · 1 center
  • Guangyou Duan — Chongqing

Publications

  • Liu J, Li L, Luo L, Wu N, Xu F, Tao C, Chen J, Huang H, Duan G. Effect of coenzyme Q10 on pain prevention after thoracoscopic surgery: study protocol. Pain Manag. 2025 Dec;15(12):889-896. doi: 10.1080/17581869.2025.2567832. Epub 2025 Sep 30. PMID 41025845

Identifiers

NCT: NCT06743802 · Coenzyme Q10 and pain

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗