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Not yet recruiting NCT06742775

Evolution of the Relationship Between Central and Peripheral Arterial Wave Velocities as a Function of Age

— Observational Aging Diagnostic Techniques, Cardiovascular

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: physiological signal acquisitions.
Who it may be relevant to
Registry conditions: Aging, Diagnostic Techniques, Cardiovascular. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Acquisition of synchronized cardiovascular signals from non-invasive measurements (ECG, photoplethysmography pulse sensors, inductance plethysmography) in healthy volunteers aged from 18 to 75, during spontaneous ventilation with apneas (20 seconds) for a total acquisition time of 30 minutes.

Interventions

  • Other physiological signal acquisitions
    Subjects will be fitted with non-intrusive devices. In a semi-recumbent position, they will be asked to perform * 10 minutes of resting breathing * 10 cycles consisting of a 20-second apnea, to be performed at the end of inspiration, and 1 minute 40 of breathing (100 seconds). This single participation session will last a total of one hour for the volunteer (equipment, recording, de-equipping), including 30 minutes of acquisition.

Primary outcome measures

  • Electrocardiogram [Time frame: 1 hour]
  • Photoplethysmography [Time frame: 1 hour]
  • inductive plethysmography [Time frame: 1 hour]
Secondary outcome measures (1)
  • link between peripheral and central pulse wave velocity [Time frame: 1 hour]

Eligibility criteria

Inclusion criteria

  • Men and women between 18 and 75 years of age
  • No acute cardiovascular pathologies less than 2 years old,
  • No chronic cardiovascular pathologies.
  • Stature compatible with the use of the plethysmography T-shirt.
  • Person affiliated to a social security scheme or beneficiary of such a scheme
  • Signed informed consent form

Exclusion criteria

  • Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L. 3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, persons under legal protection or unable to express their consent).
  • Personnel with a hierarchical link to the principal investigator
  • Subjects excluded from another study,

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

France · 1 center
  • Laboratoire TIMC — Grenoble

Publications

  • Diaz A, Galli C, Tringler M, Ramirez A, Cabrera Fischer EI. Reference values of pulse wave velocity in healthy people from an urban and rural argentinean population. Int J Hypertens. 2014;2014:653239. doi: 10.1155/2014/653239. Epub 2014 Aug 24. PMID 25215227
  • Fontecave-Jallon J, Tanguy S. Inductive Plethysmography for aortic Pulse Wave Velocity. Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:2711-2714. doi: 10.1109/EMBC44109.2020.9175329. PMID 33018566
  • Fortier C, Agharazii M. Arterial Stiffness Gradient. Pulse (Basel). 2016 Apr;3(3-4):159-66. doi: 10.1159/000438852. Epub 2015 Sep 2. PMID 27195235
  • Fortier C, Sidibe A, Desjardins MP, Marquis K, De Serres SA, Mac-Way F, Agharazii M. Aortic-Brachial Pulse Wave Velocity Ratio: A Blood Pressure-Independent Index of Vascular Aging. Hypertension. 2017 Jan;69(1):96-101. doi: 10.1161/HYPERTENSIONAHA.116.08409. Epub 2016 Nov 7. PMID 27821616
  • Heffernan KS, Stoner L, London AS, Augustine JA, Lefferts WK. Estimated pulse wave velocity as a measure of vascular aging. PLoS One. 2023 Jan 26;18(1):e0280896. doi: 10.1371/journal.pone.0280896. eCollection 2023. PMID 36701358
  • Yu S, McEniery CM. Central Versus Peripheral Artery Stiffening and Cardiovascular Risk. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1028-1033. doi: 10.1161/ATVBAHA.120.313128. Epub 2020 Mar 19. PMID 32188277
  • Weber T, Wassertheurer S, Hametner B, Parragh S, Eber B. Noninvasive methods to assess pulse wave velocity: comparison with the invasive gold standard and relationship with organ damage. J Hypertens. 2015 May;33(5):1023-31. doi: 10.1097/HJH.0000000000000518. PMID 25668350
  • Wang J, Jing C, Hu X, Cui J, Tang Q, Tu L, Zhao S, Huang J, Guo D, Li Y, Xu J. Assessment of aortic to peripheral vascular stiffness and gradient by segmented upper limb PWV in healthy and hypertensive individuals. Sci Rep. 2023 Nov 13;13(1):19859. doi: 10.1038/s41598-023-46932-0. PMID 37963909

Identifiers

NCT: NCT06742775 · 38RC24.0299

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗