Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Exercise.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 18 years — 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Genetic Determinants of Exercise-Induced Muscle Damage (POLYGENDOMUS) / Déterminants Génétiques Des Dommages Musculaires Induits Par L'exercice (POLYGENDOMUS)
Overview
The objective of this study is to evaluate the association between the evolution of plasma CPK levels and genetic polymorphisms, both before the muscle-damaging exercise and at three post-exercise time points. The investigators aim to include 300 participants in this research.
Detailed description
Elite-level sports expose athletes to training loads designed to induce muscle damage, aiming to achieve optimal physiological adaptations. However, the repetitive nature of such damage increases the risk of injury. The ability to assess an athlete's susceptibility to fragility is therefore crucial for optimizing their training and performance. Genetic factors appear to play a significant role in the occurrence of these injuries, particularly through subtle variations in DNA sequences. Depending on the location of these variations within a gene, they may or may not alter the expression or function of the associated protein. The investigators aimed to investigate the relationship between genetic polymorphisms and biological parameters in the context of exercise-induced muscle damage.
Interventions
- Other Exercise
Muscle induced-damage eccentric exercise
Primary outcome measures
- The association between single nucleotide polymorphisms and exercise induced blood creatine kinase variation [Time frame: Evolution of kinetics from Day 0 to Day 3 post experiment]
Eligibility criteria
Inclusion criteria
- Male or female
- Aged between 18 and 35
- Weighing more than 50 kg
- Member of a sports club affiliated to an Olympic federation
- Socially insured
- Willing to comply with all study procedures and duration of the study
Exclusion criteria
- Medical history contraindicating sporting activities
- Current medical treatment
- Not a member of a sports club affiliated to an Olympic federation
- Administrative reasons: impossibility of receiving informed information, impossibility of participating in the entire study, absence of social security coverage, refusal to sign consent form.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 1 center
- Eurasport — Loos
Identifiers
NCT: NCT06740136 · 2022-007 · 2022-A01308-35