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Recruiting NCT06739148

The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR

No phase Interventional Blood Flow Restriction Therapy Neuromuscular Electrical Stimulation (NMES) Laser Therapy, Low-Level Muscle Strength

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Low Level Laser Therapy, blood flow restriction, Neuromuscular Electrical Stimulation.
Who it may be relevant to
Registry conditions: Blood Flow Restriction Therapy, Neuromuscular Electrical Stimulation (NMES), Laser Therapy, Low-Level, Muscle Strength. Basic parameters: 20 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Taiwan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined Neuromuscular Electrical Stimulation and Blood Flow Restriction

Overview

Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.

Interventions

  • Device Low Level Laser Therapy
    Low-level laser therapy can increase cellular energy production, making it useful as a pre-conditioning treatment to prevent muscle contraction fatigue or as a post-contraction therapy to accelerate fatigue recovery.
  • Device blood flow restriction
    Its advantage is that during training, it can surpass the \"overload principle,\" allowing for effective muscle cross-sectional area growth with relatively light weight training (20%-50% of 1RM or 20%-40% of MVC).
  • Device Neuromuscular Electrical Stimulation
    It is a strength training method that uses electrical currents to stimulate nerve and muscle activation, helping to maintain muscle mass, increase blood flow, and slow down or prevent muscle atrophy.

Primary outcome measures

  • Myoton [Time frame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training]
  • Mechanomyogram [Time frame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training]
  • Multi-electrode surface EMG [Time frame: before training, at the end of 3 weeks training]
  • Dynamometer System [Time frame: before training, 1week of training, 2 weeks of training, at the end of 3 weeks training]

Eligibility criteria

Inclusion criteria

  • Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.
  • Normal vision range after visual correction.

Exclusion criteria

  • Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\' autonomy.
  • History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.
  • Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.
  • Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Taiwan · 1 center
  • National Chen Kong University Hospital, Tainan — Tainan

Identifiers

NCT: NCT06739148 · A-ER-113-089

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗