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Recruiting NCT06735378

Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury

No phase Interventional Hemodialysis Cardioprotection

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Intradialytic Cycling.
Who it may be relevant to
Registry conditions: Hemodialysis, Cardioprotection. Basic parameters: 18 years — 79 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Canada
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Exercise Preconditioning to Protect Against Dialysis-induced Cardiac Injury in Hemodialysis Patients: a Randomized Controlled Trial

Overview

The goal of this study is to determine what happens to the heart muscle contraction when people cycle before their hemodialysis treatment. Will pre-dialysis exercise protect the heart from a decrease in pumping of the heart muscle (called stunning) that can happen during hemodialysis. We will study whether pre-dialysis exercise decreases heart stunning, decreases the number and severity of symptoms commonly associated with hemodialysis, and other outcomes

Detailed description

This will be the first randomized crossover-controlled trial with two experimental conditions assessing the impact of exercise preconditioning in the HD population. If proven effective exercise preconditioning could be developed as a therapeutic option to reduce rates of heart failure in the dialysis population.

Interventions

  • Other Intradialytic Cycling
    The impact of interdialytic exercise on cardio protection during HD has never been studied. This approach may enhance cardiovascular benefits and overall physical fitness, thereby contributing to better health outcomes in individuals undergoing HD.

Primary outcome measures

  • Change in the number of left ventricular segments undergoing a greater than 20% reduction in longitudinal strain as detected by echocardiogram [Time frame: week 1 to week 4]
Secondary outcome measures (7)
  • Evaluate potential targets of preconditioning by exercise-induced cardio protection by focusing on hemodynamics (Blood Pressure) [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardio protection focusing on hemodynamics (CV Insight Monitoring), [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardioprotection, focusing on hemodynamics (Finapres) [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardio protection, focusing on blood markers [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardio protection, focusing on erythrocyte deformability [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardio protection, focusing on endothelial function [Time frame: week 1 to week 4]
  • Evaluate potential targets of preconditioning by exercise-induced cardioprotection, focusing on proteomic analysis. [Time frame: week 1 to week 4]

Eligibility criteria

Inclusion criteria

  • must be on chronic hemodialysis for at least 3 months
  • age 18 years or older
  • willing and able to provide informed consent
  • assessed to be safe and able to exercise by unit HD Nephrologist

Exclusion criteria

  • regular vigorous exercise outside of hemodialysis
  • over 79 years of age
  • intradialytic exercise < 3 months
  • poor echogenicity
  • acute coronary syndrome in the past 3 months
  • unstable arrhythmia/angina
  • shortness of breath at rest or with minimal activity
  • symptomatic hypoglycemia (>2x/week in the week prior to enrolment)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Prevention

Study locations

Canada · 1 center
  • London Health Sciences Centre — London

Identifiers

NCT: NCT06735378 · 15393

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗