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Not yet recruiting NCT06722092

VR and Scrip Training of PWA, Randomized Controlled Trial

No phase Interventional Aphasia, Acquired Chronic Stroke

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: VR-based script training, Conventional script training.
Who it may be relevant to
Registry conditions: Aphasia, Acquired, Chronic Stroke. Basic parameters: 30 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Can Immersive Virtual Reality Magnify Treatment Outcomes of Script Training on Cantonese Speakers with Chronic Aphasia: a Randomized Controlled Trial

Overview

The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes. The main research questions are: 1. Can script training promote verbal functional communication of Cantonese-speaking PWA? 2. Can script training enhance nonverbal cognitive functions of Cantonese-speaking PWA? 3. Can VR magnify verbal and nonverbal treatment outcomes of script training of PWA?

Interventions

  • Behavioral VR-based script training
    The PWA will wear a head-mounted VR device (e.g., Metaverse Oculus Quest 2 or other commercially available devices) for 30 minutes, which intends to create an immersive environment for training. Scripts trained in the computerized script training program in a particular session will be practiced. Cinematic 360˚ photo-real scenarios of daily contexts such as a restaurant or a grocery store will be displayed in the device while a communication partner, e.g., a waiter in the restaurant or a shopkee
  • Behavioral Conventional script training
    The flow of training is identical to the VR condition, except that photos depicting the scenarios and prerecorded conversational turns will be presented to the PWA on a computer screen with the same procedures mentioned in the VR condition.

Primary outcome measures

  • Percentage accuracy of treatment probe correctly produced [Time frame: From baseline up to 8-week post training]
  • Time to produce each of the scripts in the treatment probe [Time frame: From baseline up to 8-week post training]
  • Number of sessions to reach performance criteria in session probe [Time frame: From baseline up to 8-week post training]
Secondary outcome measures (7)
  • Cantonese version of the Western Aphasia Battery (CAB) to measure aphasia severity [Time frame: From baseline up to 8-week post training]
  • Cantonese version of the Amsterdam-Nijmegen Everyday Language Test to measure verbal communication effectiveness in conversation via 20 culturally appropriate scenarios [Time frame: From baseline up to 8-week post training]
  • Cantonese version of the 20-item Communication Outcome after Stroke (Can-COAST) as a self-reported outcome on communication and quality of life [Time frame: From baseline up to 8-week post training]
  • Subtest 1 (map search) and 3 (elevator counting) of Test of Everyday Attention to assess attention [Time frame: From baseline up to 8-week post training]
  • Digit span forward and backward task to assess verbal short-term and working memory [Time frame: From baseline up to 8-week post training]
  • Test of Nonverbal Intelligence-third edition (TONI-3) to assess executive function [Time frame: From baseline up to 8-week post training]
  • Wisconsin Card Sort Test (WCST) to assess executive function [Time frame: From baseline up to 8-week post training]

Eligibility criteria

Inclusion criteria

  • a stroke onset more than six months, with an Aphasia Quotient (AQ) below 96.4, as evaluated by the Cantonese version of Western Aphasia Battery (CAB; Yiu, 1992),
  • premorbid fluent Cantonese speakers,
  • aged between 30 and 80 years,
  • no reported progressive neurogenic disorders such as dementia or Parkinson's disease,
  • no motor speech disorders of moderate to severe level, and
  • normal or corrected-to-normal vision and hearing functions

Exclusion criteria

  • concurrent participation in other aphasia treatment trials, and
  • incompatibility with immersive VR exposure such as complains of nausea, headache, or other severe discomforts during trial use of a head-mounted device during screening.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Center list to be confirmed — check the primary protocol.

Publications

  • Wong WWS, Li DSP, Fong KNK, Ng PHF, Kwok HTK. Can immersive virtual reality magnify treatment outcomes of computerized script training on Cantonese speakers with chronic aphasia? Protocol of a randomized controlled trial. PLoS One. 2026 Jun 2;21(6):e0350390. doi: 10.1371/journal.pone.0350390. eCollection 2026. PMID 42228712

Identifiers

NCT: NCT06722092 · HSEARS20230228003-01

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗