Walking Program in Fatty Liver Children With Phenylketonuria
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: walking free online supervised program.
- Who it may be relevant to
- Registry conditions: Phenylketonurias, Non Alcoholic Fatty Liver. Basic parameters: 9 years — 12 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Walking Program in Fatty Liver Children With Phenylketonuria: Response of Liver Enzymes
Overview
phenylketonuria (commonly known as PKU) is an inherited disorder that increases the levels of a substance called phenylalanine in the blood. PKU is usually associated with many metabolic complication including non-alcoholic fatty liver
Detailed description
this study will include PKU children sufferers 9n=40) with non-alcoholic fatty liver to be randomly assigned to group I (n=20) that will perform walking program (online supervised free walking that will be applied daily for eight weeks) or group II (N=20) that will act as waitlisted children
Interventions
- Behavioral walking free online supervised program
this Group I will include PKU children sufferers (n=20) with non-alcoholic fatty liver that will perform walking program (online supervised free walking that will be applied daily for eight weeks)
Primary outcome measures
- alanine transamianse [Time frame: it will be assessed after eight weeks]
Secondary outcome measures (5)
- aspartate tranaminase [Time frame: it will be assessed after eight weeks]
- Gamma-glutamyl Transferase [Time frame: it will be assessed after eight weeks]
- alkaline phosphatase [Time frame: it will be assessed after eight weeks]
- triglycerides [Time frame: it will be assessed after eight weeks]
- body mass index [Time frame: it will be assessed after eight weeks]
Eligibility criteria
Inclusion criteria
- PKU children
- obese children
- fatty liver children (non-alcoholic fatty liver)
Exclusion criteria
- cardiac children
- diabetic children
- neurogenic disorders
- respiratory and renal problems
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Cairo University — Dokki
Publications
- Ali Ismail AM, Gohary MM, Mabrouk Bondok SM, Abo Elatta AB, Ahmed El Gressy NSS, El Melhat AM, El-Sayed Felaya EE. Effect of walking exercise on liver enzymes in children with phenylketonuria and non-alcoholic fatty liver disease: A randomized controlled trial. Med Clin (Barc). 2026 Apr;166(4):107395. doi: 10.1016/j.medcli.2026.107395. Epub 2026 Mar 6. English, Spanish. PMID 41793924
Identifiers
NCT: NCT06718842 · P.T.REC/012/005449