The Effect of Coffee on People with High Intensity Exercise and the Characteristics of Caffeine Metabolism
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Caffeine content.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 18 years — 40 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this project is to explore the relationship between the effect of coffee on exercise performance and caffeine metabolism.
Detailed description
The investigators will study the relationship between the impact of coffee on exercise and caffeine metabolism. The investigators will recruit healthy elite athletes. Participants will be forbidden to consume stimulant drinks such as coffee for 24 hours before the experiment. When the participants arrive at the lab on the day of the experiment, they will sign an informed consent form, a health history questionnaire and a daily coffee consumption questionnaire. Each participant does six rides, with one day of caffeine washout before each ride. In all trials, each participant will ride at the same time of day. Before riding, drink 200 ml water, decaffeinated coffee or coffee in random order, and the caffeine content of coffee is 200 mg. After 60 minutes of drinking, they start riding, after the completion of the riding, the subjects perceived and judged the perception between the baseline load and the comparison load. After the completion of the judgment, the next level of stimulus parameters will randomly generated to conduct the experiment. Each person conducted 6 groups of intervention experiments. Changes in average exercise performance, heart rate, electrocardiogram and body temperature will be observed after drinking decaffeinated coffee or coffee compared with drinking water. The concentration of caffeine and its metabolites in urine before and after drinking within 3 hours will be measured by liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS).
Interventions
- Other Caffeine content
Participants will drink the same volume of water or coffee with different amounts of caffeine.
Primary outcome measures
- Exercise performance [Time frame: On the experimental day, it lasts 2 weeks.]
- Urine metabolites [Time frame: On the experimental day, it lasts 2 weeks.]
Secondary outcome measures (10)
- Body temperature [Time frame: On the experimental day, it lasts 2 weeks.]
- Electrocardiogram (ECG) [Time frame: On the experimental day, it lasts 2 weeks.]
- Blood pressure [Time frame: On the experimental day, it lasts 2 weeks.]
- Height [Time frame: The morning of the first day of the experiment, 5 mins]
- Body weight [Time frame: The morning of the first day of the experiment, 5 mins]
- Fat mass [Time frame: The morning of the first day of the experiment, 10 mins]
- Fat free mass [Time frame: The morning of the first day of the experiment, 10 mins]
- Bone mass [Time frame: The morning of the first day of the experiment, 10 mins]
- Heart rate [Time frame: 2 weeks]
- Waist circumferences [Time frame: The morning of the first day of the experiment,10 mins]
Eligibility criteria
Inclusion criteria
Healthy adults 18-40 years old
Exclusion criteria
Diabetes Hypoglycemia Gout Osteoporosis Gastric ulcer Pancreatitis Intestinal obstruction Blood phobia Pathological hypo or hyper tension Impaired glucose tolerance Claustrophobia HIV,etc.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
China · 1 center
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences — Shenzhen
Identifiers
NCT: NCT06712667 · SIAT IRB240915H0915