Different Methods of Capecitabine in Patients With Non-PCR After Neoadjuvant Therapy for TNBC
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: capecitabine.
- Who it may be relevant to
- Registry conditions: Triple Negative Breast Cancer. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Cohort Study of Different Methods of Adjuvant Capecitabine Regimens in Patients With Non-PCR After Neoadjuvant Therapy for Triple Negative Breast Cancer
Overview
The survival rate of patients with pathological complete response (pCR) after neoadjuvant therapy was significantly better than that of patients with tumor residue, that is, non-pCR patients. Therefore, studies have confirmed that intensive adjuvant therapy for patients with non-pCR after neoadjuvant chemotherapy can further improve the survival of this population. Previous studies have given capecitabine treatment to such patients as standard. However, it is unknown whether capecitabine intensification still has the same status under the premise that most patients receive immunotherapy at the neoadjuvant stage; Whether there are differences in the efficacy and safety of capecitabine standard 6-8 cycle intensive regimen and capecitabine metronomic chemotherapy are practical problems encountered in clinical practice. This study explored the efficacy and safety of 6-8 cycles of full dose capecitabine intensive therapy compared with 1-year capecitabine metronomic chemotherapy in patients with T2 and above and/or lymph node positive early triple negative breast cancer who still had invasive tumor after neoadjuvant therapy.
Interventions
- Drug capecitabine
different methods of treatment for capecitabine
Primary outcome measures
- disease free survival [Time frame: 5 years]
Secondary outcome measures (4)
- invasive disease free survival [Time frame: 5 years]
- distant disease free survival [Time frame: 5 years]
- breast cancer specific survival [Time frame: 5 years]
- overall survival [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- 1\) Patients with triple negative breast cancer diagnosed by biopsy in Peking University People's Hospital;
- 2\) The clinical stages before treatment were T1-T4, N0-N3, M0;
- 3\) Received treatment and operation in our hospital, and had hospitalization records;
- 4\) Neoadjuvant chemotherapy is unlimited, and immunotherapy is allowed in neoadjuvant and/or adjuvant treatment;
- 5\) Postoperative pathology confirmed the presence of residual invasive breast cancer in the breast and/or axillary lymph nodes;
- 6\) Has signed and agreed to participate in the PKUPH breast disease cohort study.
Exclusion criteria
- 1\) Lack of clinical and pathological data (such as imaging data and pathological data);
- 2\) Patients with metastatic breast cancer or bilateral breast cancer;
- 3\) Failure to perform radical surgery;
- 4\) BRCA has pathogenic or possibly pathogenic mutations, and received intensive treatment with PARP inhibitors after operation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Peking University People's Hospital — Beijing
Identifiers
NCT: NCT06700382 · PKUPH2024Z167