ReadMap: Reading in Stroke Alexia and Typical Aging
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aphasia, Stroke, Alexia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for pleasure, and reading signs in the community. Understanding the brain and cognitive basis of alexia could improve diagnosis and treatment of this important problem. In this study, the investigators will perform a large-scale behavioral and brain imaging study of stroke survivors and typical older adults to improve our understanding of the brain and cognitive basis of reading in both of these groups. Participants will complete a battery of tests of reading, speech, language, and thinking abilities. In addition, some participants will complete an MRI. Sessions will be completed across approximately 2-6 weeks, but may be extended depending on participants' schedules and availability. Some participants will be invited to repeat these procedures once or twice in approximately 3-12 months to monitor for changes in reading abilities and MRI measurements over time.
Primary outcome measures
- MP-RAGE (Magnetization Prepared Rapid Acquisition Gradient Echo) [Time frame: Collected within 1 month of behavioral testing]
- DTI (Diffusion Tensor Imaging) [Time frame: Collected within 1 month of behavioral testing]
- Behavioral testing [Time frame: Collected within 1 month of MRI]
Eligibility criteria
Inclusion criteria
Stroke Survivors:
- Age >= 18
- Learned English at 8 years or younger
- Brain injury resulting from stroke
Controls:
- Age >= 18
- Learned English at 8 years or younger
Exclusion criteria for all groups:
- History of other brain disorder that could interfere with our ability to interpret results (e.g., Multiple sclerosis, dementia, head injury causing loss of consciousness)
- Severe psychiatric condition that would interfere with participation in the study
- History of diagnosed learning disorder
- Hearing or vision loss that interferes with performance on behavioral tests even after correction with glasses/hearing aids.
- Inability to follow study procedures despite maximal support
Additional exclusion criteria for MRIs:
- Presence of metal in the body that is incompatible with MRI
- Pregnancy
- Claustrophobia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- Georgetown University Medical Center — Washington D.C.
Identifiers
NCT: NCT06700005 · ReadMap · R01DC020446