Menu
Not yet recruiting NCT06693141

Effects of Erector Spinae Plane Block and Intrathecal Morphine Administration on Intraoperative Sevoflurane Consumption

— Observational Postoperative Pain Anesthesia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: ESP block, ITM.
Who it may be relevant to
Registry conditions: Postoperative Pain, Anesthesia. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Comparison of the Effects of Erector Spinae Plane Block and Intrathecal Morphine Administration on Intraoperative Sevoflurane Consumption in Disc Surgeries

Overview

In our study, the investigators aimed to compare the intraoperative sevoflurane consumption and postoperative analgesic needs of patients who underwent lumbar disc herniation surgery and received either ESP block or ITM in the preoperative period with a control group.

Detailed description

The amount of volatile anesthetic agents used for anesthesia maintenance can be significantly reduced with potent and long-acting analgesic interventions administered during the preoperative period. Such interventions enable the maintenance of anesthesia with more optimal levels of agents during surgery, providing significant advantages in terms of both patient safety and cost.

Studies have recommended multimodal analgesia approaches involving the Erector Spinae Plane (ESP) block and intrathecal morphine (ITM) injection for various surgical procedures. These two methods, through different mechanisms of action, not only reduce intraoperative anesthetic agent consumption but also play a critical role in postoperative pain management. Although studies have investigated the effects of ESP block and ITM injection on intraoperative volatile anesthetic consumption, there is limited research directly comparing their impacts on volatile anesthetic consumption and postoperative analgesic requirements.

In our study, we aimed to compare the intraoperative sevoflurane consumption and postoperative analgesic needs of patients who underwent lumbar disc herniation surgery and received either ESP block or ITM in the preoperative period with a control group.

Interventions

  • Other ESP block
    ESP block was applied to the patients.
  • Other ITM
    ITM was applied to the patients.

Primary outcome measures

  • Intraoperative Sevoflurane consumption [Time frame: 60 minutes after anesthesia induction]
Secondary outcome measures (5)
  • Rescue analgesic consumption [Time frame: 2 hours postoperatively]
  • Rescue analgesic consumption [Time frame: 4 hours postoperatively]
  • Rescue analgesic consumption [Time frame: 8 hours postoperatively]
  • Rescue analgesic consumption [Time frame: 12 hours postoperatively]
  • Rescue analgesic consumption [Time frame: 24 hours postoperatively]

Eligibility criteria

Inclusion criteria

  • Patients aged over 18 years
  • Patients receiving general anesthesia
  • Patients with an ASA score of I-II
  • Patients undergoing elective surgery for single-level lumbar disc herniation
  • Patients who provided informed consent after being informed

Exclusion criteria

Patients who did not provide informed consent after being informed

  • Patients over 65 years of age
  • Patients with an ASA score of III or higher
  • Patients with recurrent lumbar disc herniation (LDH)
  • Patients undergoing surgery for multi-level LDH
  • Patients with a body mass index (BMI) of 30 or higher
  • Patients with allergies to morphine or bupivacaine
  • Patients with major cardiac, respiratory, hepatic, renal, neurological, or psychiatric diseases
  • Patients with a history of alcohol or substance abuse
  • Patients with a local infection at the injection site
  • Patients with bleeding diathesis
  • Patients with a history of anticoagulant medication use
  • Patients with contraindications to spinal or regional anesthesia

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Study design

Observational model
Case-control

Study locations

Turkey (Türkiye) · 1 center
  • Ankara Etlik City Hospital — Ankara

Publications

  • Yorukoglu HU, Icli D, Aksu C, Cesur S, Kus A, Gurkan Y. Erector spinae block for postoperative pain management in lumbar disc hernia repair. J Anesth. 2021 Jun;35(3):420-425. doi: 10.1007/s00540-021-02920-0. Epub 2021 Mar 22. PMID 33751203
  • Lal A, Singh MK, Kanaujia SK, Mishra NK, Singh BP, Singh GP. Comparison of Intrathecal Morphine Versus Erector Spinae Plane Block for Perioperative Analgesia in Patients Undergoing Lumbar Spine Surgery: A Randomized Control Trial. Cureus. 2024 Jul 17;16(7):e64775. doi: 10.7759/cureus.64775. eCollection 2024 Jul. PMID 39156461
  • Nashibi M, Sezari P, Safari F, Teymourian H, Asgari S, Mottaghi K. The effect of erector spinae plane block on the use of anesthetic medications in lumbar spine surgery. Agri. 2023 Oct;35(4):228-235. doi: 10.14744/agri.2022.48992. PMID 37886866

Identifiers

NCT: NCT06693141 · Bengü Tez

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗