Research on the Characteristics of Chronic Airway Diseases (asthma, COPD)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Participants fill out the questionnaire.
- Who it may be relevant to
- Registry conditions: Asthma Bronchiale, Chronic Obstructive Pulmonary Disease (COPD). Basic parameters: 12 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Research on the Syndrome Characteristics of Chronic Airway Diseases (asthma, Chronic Obstructive Pulmonary Disease) Based on Intelligent Algorithm Fusion of Phenotype Omics
Overview
This study will to investigate the correlation between the characteristics of the population with chronic airway diseases (asthma, chronic obstructive pulmonary disease) and syndromes, in order to reveal the disease and syndrome features of the population; Secondly, screening and identifying biomarkers for asthma and chronic obstructive pulmonary disease to provide a basis for precise prevention and treatment of the disease.
Detailed description
Chronic airway diseases are a group of non-specific chronic airway inflammatory diseases, with a heavy disease burden and serious harm to public health. Bronchial asthma and chronic obstructive pulmonary disease are the most common and representative chronic airway diseases, with significant clinical heterogeneity and unclear disease syndrome relationships. Clarifying the characteristics of asthma and chronic obstructive pulmonary disease populations, disease features, syndrome features, and their interrelationships is an important prerequisite for achieving personalized treatment and improving efficacy. Therefore, this study adopted a stratified random sampling clinical epidemiological survey method, selecting more than 10000 asthma and chronic obstructive pulmonary disease patients nationwide, and applying an optimized respiratory disease intelligent clinical research platform to collect patient population data (age, respiratory disease history, etc.), disease information (staging, grading, typing), and syndrome information (empirical, deficiency, and mixed syndrome). Using intelligent algorithms such as high-dimensional Bayesian optimization MCC-BO, T-distribution random nearest neighbor embedding, multidimensional correlation analysis, etc. to analyze the correlation between population characteristics and diseases and syndromes; Elucidate the correlation points between different stages, grades, types, and syndromes of asthma and chronic obstructive pulmonary disease. Using phenomics and adaptive multi omics global similarity fusion method to identify their biomarkers, further revealing the disease characteristics of asthma and chronic obstructive pulmonary disease populations, and guiding the precise treatment of traditional Chinese and Western medicine.
Interventions
- Other Participants fill out the questionnaire
Participants fill out the questionnaire
Primary outcome measures
- Inflammatory Phenotype of Chronic Airway Diseases [Time frame: Each registered patient is measured only once at the time of registration.]
- The Traditional Chinese Medicine Syndromes of Athma [Time frame: Each registered patient is measured only once at the time of registration.]
- The Traditional Chinese Medicine Syndromes of COPD [Time frame: Each registered patient is measured only once at the time of registration.]
- General Demographic Data [Time frame: Each registered patient is measured only once at the time of registration.]
- Asthma Control Test (ACT) [Time frame: Each registered patient is measured only once at the time of registration.]
- COPD Assessment Test (CAT) [Time frame: Each registered patient is measured only once at the time of registration.]
- Clinical Symptoms and Signs Questionnaire [Time frame: Each registered patient is measured only once at the time of registration.]
- modified Medical Research Council (mMRC) [Time frame: Each registered patient is measured only once at the time of registration.]
- Forced Expiratory Volume in One Second (FEV1) [Time frame: Each registered patient is measured only once at the time of registration.]
- Forced Vital Capacity (FVC) [Time frame: Each registered patient is measured only once at the time of registration.]
Eligibility criteria
Inclusion criteria
- Meets the diagnostic criteria for asthma or COPD.
- Age of athma range from 12 years to 80 years.Age of COPD range from 18 years to 80 years.
- The investigators agreed to participate in this clinical study by voluntarily signing an informed consent form.
Exclusion criteria
- Patients with respiratory diseases such as interstitial lung disease, lung malignant tumor, lung infectious diseases, pneumothorax, pleural effusion, etc., which affect the syndrome differentiation.
- Patients with combining severe cardiovascular and cerebrovascular diseases, severe liver and kidney diseases, severe hematological malignancies, etc., affecting syndrome differentiation.
- Patients with delirium, dementia, various mental illnesses.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06685315 · Chronic Airway Disease