Telerehabilitation In The Home After Stroke

Official title

Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial

Overview

The purpose of this research study is to evaluate whether telerehabilitation targeting arm movement, when added to usual care, improves arm function and reduces global disability after stroke, compared to usual care alone. Patients with arm weakness due to stroke that happened in the past 90-150 days will be randomized into one of two groups: \[1\] TR and usual care; \[2\] usual care only (no TR), but people in the usual care group will be offered TR once the study is done. TR consists of 70 minutes/day of activities targeting arm function, 6 days a week for 6 weeks.

Detailed description

This is a randomized, assessor-blinded study that involves the use of telerehabilitation to deliver additional therapy for persons with stroke. Patients with arm weakness due to stroke that happened in the past 90-150 days will be randomized into one of two groups: \[1\] TR and usual care; \[2\] usual care only (no TR), but people in the usual care group will be offered TR once the study is done. TR consists of 70 minutes/day of activities targeting arm function, 6 days a week 6-8 weeks. The hypothesis of this study is patients receiving TR in addition to their usual care will have significantly greater recovery of arm function compared to patients receiving usual care alone.

Study participation will last approximately 8 months and includes 4 in-person visits. At these visits, patients will undergo a variety of assessments including tests of arm function and a single MRI scan of the brain. Patients undergoing TR will receive arm motor training, which consists of 36 sessions of assigned exercises, games, and stroke education; these total 70 minutes in length and occur 6 days a week for 6 weeks; TR subjects will also continue usual care. Patients in the usual care group only will not engage in TR but will instead continue all of the therapies recommended by their medical team. At the end of the study, participants in the usual care group will be offered TR.

Interventions

• Device Telerehabilitation
  The telerehabilitation system will deliver rehabilitation treatment sessions via a secured internet-connected computer. TR sessions will be a combination of games, exercises, stroke education, assessments, in addition to videoconferencing with therapists to discuss progress, issues, goals, and changes to the treatment plan.

Primary outcome measures

• Change in Action Research Arm Test (ARAT) Score from Baseline to 2 Months [Time frame: 2 months]

Secondary outcome measures (1)

• Change in modified Rankin Scale (mRS) Score from Baseline to 2 Months [Time frame: 2 months]

Eligibility criteria

Inclusion criteria

• Age 18-80 years at the time of randomization
• The index stroke was radiologically verified, due to ischemia or intracerebral hemorrhage (ICH), and had time of onset 120±30 days prior to randomization
• The stroke caused upper extremity deficits as defined by Action Research Arm Test score 18-44 (out of 57) at Baseline Visit 1
• Box \& Block Test score with affected arm is ≥1 block in 60 seconds at Baseline Visit 1
• Able to successfully perform all 3 rehabilitation exercise test examples (simple commands) at Baseline Visit 1
• Informed consent and behavioral contract signed by the subject (i.e., no surrogate consent)

Exclusion criteria

• A major, active, coexistent neurological, psychiatric, or medical disease that reduces the likelihood that a subject will be able to comply with all study procedures
• Unable or unwilling to perform study procedures/therapy, or expectation of noncompliance with study procedures/therapy, or expectation that subject cannot participate in all study visits
• A diagnosis (apart from the index stroke) that substantially affects paretic arm function
• Severe depression, defined as Geriatric Depression Scale Score >10/15 at Baseline Visit 1
• Significant cognitive impairment, defined as Montreal Cognitive Assessment score <22 \[a lower score is permitted if due to aphasia and allowed by the site PI\]
• Deficits in communication that interfere with reasonable study participation
• Severe UE spasticity, defined as presence of contracture or modified Ashworth Scale score=4 in either biceps or pectoralis
• Modified Rankin Scale score was >2 prior to the index stroke
• A new symptomatic stroke has occurred since the index stroke, or a separate stroke occurred within 30 days prior to the index stroke
• Lacking visual acuity, with or without corrective lens, of 20/50 or better in at least one eye
• Life expectancy < 9 months
• Pregnant; women of child-bearing potential must have a negative pregnancy test
• Botulinum toxin to the paretic arm: received in the prior 3 months OR expected by the 8-Month Visit
• Concurrent enrollment in another therapy-based investigational study where the duration of the investigational therapy's activity is likely to occur during the subject's participation in the study
• Subject lacks sufficient English or Spanish to comply with study procedures and TR instructions
• Expectation that subject will not have a single domicile address during the 6 weeks of therapy that is within 1.5-hr drive of the central study site \[this can be waived at the discretion of the site PI\]
• Contraindication to MRI
• On isolation precautions, e.g., due to active COVID-19

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation

Randomized

Model

Parallel assignment

Masking

Single blind

Primary purpose

Treatment

Study locations

United States · 27 centers

• Rancho Los Amigos Research Institute — Downey
• University of California, Irvine — Irvine
• Keck Medical Center of USC — Los Angeles
• University of California, Los Angeles — Los Angeles
• Casa Colina Hospital and Centers for Healthcare — Pomona
• Hillcrest Medical Center at UC San Diego Health — San Diego
• Medstar Health Research Institute — Washington D.C.
• Brooks Rehabilitation Hospital — Jacksonville
• … and 19 more centers

Identifiers

NCT: NCT06682429 · Q221354

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗