Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: carbon monoxide measurement via smokerlyzer.
- Who it may be relevant to
- Registry conditions: Liver Cancer Adult, Liver Regeneration. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Overview
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Interventions
- Other carbon monoxide measurement via smokerlyzer
participants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection
Primary outcome measures
- correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration [Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection]
Secondary outcome measures (3)
- level of carbon monoxide in exhaled air of patients [Time frame: measurements will be taken pre, then 4 hours and 24 hours post resection]
- quantity of liver regeneration, liver volume (ml) [Time frame: one and three months after resection]
- quality of hepatic regeneration, normalized liver function [Time frame: one and three months post resection]
Eligibility criteria
Inclusion criteria
- Patient plans to have partial liver resection for primary liver pathology or metastatic disease
- Patient is able to comprehend and willing to sign the written consent form
Exclusion criteria
- Patients < 18 years
- Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Englewood Hospital — Englewood
Identifiers
NCT: NCT06681818 · E-24-982