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Recruiting NCT06680895

FeNO Observation Study in ICU Patients With ARS

— Observational Compare the Concentration of Exhaled Nitric Oxide in Patients With Different Severity of RF

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: FeNO Observation.
Who it may be relevant to
Registry conditions: Compare the Concentration of Exhaled Nitric Oxide in Patients With Different Severity of RF. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

An Observational Study of Fractional Exhaled Nitric Oxide Concentration in Patients With Advanced Respiratory Support

Overview

1. Main Objective: To compare the concentration of exhaled nitric oxide in patients with different severity of respiratory failure in ICU. 2. Secondary Purpose: 1. To observe the change of nitric oxide concentration in exhaled breath of patients with mechanical ventilation over time; 2. The relationship and differences between pulmonary ventilation blood flow levels in patients with different exhaled NO concentrations; 3. Reactivity of patients with different exhaled NO concentrations to inhaled nitric oxide therapy and the relationship between them.

Interventions

  • Other FeNO Observation
    FeNO was observed and measured among patients with advanced respiratory support

Primary outcome measures

  • FeNO concentration [Time frame: 1.5 year]

Eligibility criteria

Inclusion criteria

  • Adult patients (≥18 years of age) with mechanical ventilation or advanced respiratory support in the ICU, regardless of gender;
  • The expected mechanical ventilation time of tracheal intubation is more than 24 hours;
  • The initial ventilator Settings of clinical routine were adopted: oxygen fraction (FIO2) = 50%, respiratory rate = 15/min, positive end-expiratory pressure (PEEP) = 5 cmH2O, tidal volume = 6-8 ml/kg ideal body weight (IBW), inspiration-exhalation ratio =1:2;
  • Agree to participate in this experiment and sign the informed consent.

Exclusion criteria

  • 1.Use of any NO-containing drugs (such as nitroglycerin), anti-inflammatory drugs, or drugs or means that affect the airway diameter within 6 hours before the first FeNO measurement; 2. Participating in other clinical research projects; 3. Patients deemed unsuitable by the investigators.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Study design

Observational model
Case-only

Study locations

China · 1 center
  • Shanghai Zhongshan hospital — Shanghai

Identifiers

NCT: NCT06680895 · ShanghaiZhongshanICU

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗