Recruiting NCT06678360

Perioperative Impact of Physical Activity on Short- and Long-term Morbidity and Mortality

— Observational General Surgery Perioperative Complication Perioperative Medicine Physical Inactivity

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to: Registry conditions: General Surgery, Perioperative Complication, Perioperative Medicine, Physical Inactivity. Basic parameters: from 18 years · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: Sweden
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Official title

Perioperative Impact After Non-cardiac Surgery of Physical Activity on Short- and Long-term Morbidity and Mortality

Overview

Over 300 million surgeries are performed globally every year. Complications after surgery - infections, cardiovascular conditions, postoperative pulmonary complications and renal impairment - affect survival and quality of life. Age and co-morbidity are unmodifiable factors, contributing to increased risk of these perioperative complications. However, a modifiable risk factor is physical activity. This study aims to test if self reported physical activity is associated to lower risk of perioperative morbidity and mortality.

Detailed description

Research question: This cohort study investigates if higher levels of self reported physical activity at preoperative assessment is associated to lower risk of complications and lower mortality.

Background: Previous studies of perioperative outcomes in high-income countries indicate that close to 20% had complications within 30 days after surgery, and that around 3% died within 1 yr after surgery. In multiple studies, postoperative complications massively increase risk of 1yr mortality. Whilst perioperative complications are under-reported, they affect length of stay and days at home up to 30 days after surgery (DAH30). DAH30 is a validated, patient-centered outcome measure with prognostic importance due to high sensitivity to changes in surgical risks and the impact of surgical complications.

Data collection: Age, sex, body mass index, co-morbid conditions (using ICD-codes and reported medication) as well as American Society of Anesthesiologists (ASA) physical status classification will be recorded. Exposure: the Metabolic Equivalent of Task Score (MET-score), reported in the electronic health record by the attending anesthesiologist based on patient history in conjunction with the preoperative assessment.

Analysis: The MET-score is the exposure/the dependent variable and the other factors will be used in multivariable analyses.

Primary outcome measures

Mortality [Time frame: Mortality will be recorded at 30, 60, 90 and 365 days after index surgery]
DAH30 (Days At Home alive at 30 days) [Time frame: 30, 90 and 365 days after index surgery,]

Secondary outcome measures (1)

Length of stay [Time frame: One year after index surgery]

Eligibility criteria

Inclusion criteria

Adult patients (equal to or over 18 years) undergoing elective non-cardiac surgery at the two study sites, Karolinska University Hospital Solna and Karolinska University Hospital Huddinge

Exclusion criteria

Patients under the age of 18, transplant, day surgery, acute surgery, anesthesia monitoring, brachy therapy and gamma knife interventions. In case of multiple surgeries, only the first will be included.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model: Cohort

Study locations

Sweden · 1 center

Karolinska Institutet — Stockholm

Publications

Valadkhani A, Sebghati S, Piehl J, Bell M. Impact of Preoperative Functional Capacity on Postoperative Mortality and Morbidity: A Prospective Cohort Study. Anesthesiology. 2026 Mar 1;144(3):525-534. doi: 10.1097/ALN.0000000000005779. Epub 2025 Oct 3. PMID 41043174

Identifiers

NCT: NCT06678360 · PeriopIPA Karolinska

Primary sources (government registries)

ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗