Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: running.
- Who it may be relevant to
- Registry conditions: Marathon Runner. Basic parameters: 20 years — 65 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Gut-muscle Axis: Exploring the Gut Microbiota Influences Host Energy Sources and Exercise Performance Via Modulation of Lactate Metabolism and Utilization
Overview
Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science. This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.
Detailed description
The gut microbiota, which is comprised of trillions of microbes, is the collective term for the gut microbiota. It establishes a symbiotic relationship with the host and plays a vital role in maintaining host health. Through training, the investigators can adjust the composition and functions of gut microbiota. Exercise also alters the body's energy metabolism pathways, which, in turn, impacts the gut microbiota and its metabolic products. Understanding how the body utilizes and regulates energy during exercise is essential for enhancing athletic performance. This study aims to explore the relationships among post-exercise energy metabolites, gut microbiota, and their metabolic products, applying omics technologies in the field of sports science.
This interdisciplinary research will contribute to fields such as exercise physiology, sports nutrition, exercise biochemistry, and sports medicine, providing innovative and practical research insights for advancing sports science in our country.
Interventions
- Device running
Running 10 kilometers on a treadmill
Primary outcome measures
- Concentration of lactate [Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, immediately after exercise, and at 5, 15, 30, and 60 minutes post-exercise.]
- Concentration of creatine kinase [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of glucose [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of creatinine [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of blood urea nitrogen [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of lactate dehydrogenase [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of free fatty acid [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- Concentration of cortisol [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and 60 minutes post-exercise.]
- ood frequency questionnaire(FFQ) [Time frame: Before exercise]
- Gut microbiota analysis [Time frame: The testing time points are set as follows: before exercise, immediately after exercise, and at 24 and 48 hours post-exercise.]
Secondary outcome measures (3)
- Body composition [Time frame: Before exercise]
- Rate of Perceived Exertion(RPE) [Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.]
- Heart rate [Time frame: The testing time points are set as follows: before exercise, at the 5-kilometer mark during exercise, and immediately after exercise.]
Eligibility criteria
Marathon Running Group
Inclusion criteria
- Training frequency of at least 3 times per week in the past year, with each session involving at least 1 hour of running.
- Participation in at least 2 marathon events within the past 2 years, with a completion time of under 4 hours and 30 minutes for a full marathon, or under 2 hours and 15 minutes for a half marathon.
Exclusion criteria
- Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
- Habitual smokers.
- Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
- History of chronic neuro-muscular injuries or disorders in the past 6 months.
- Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.
General Healthy Adult Group
Inclusion criteria
- Generally healthy, untrained individuals.
Exclusion criteria
- Excludes individuals with cardiovascular diseases, hypertension, epilepsy, bronchitis, severe asthma, heart disease, inflammatory bowel disease, bacterial or viral infections, disabilities, or chronic bone diseases.
- Habitual smokers.
- Individuals with highly irregular eating habits or sleep patterns due to shift work or night work.
- History of chronic neuro-muscular injuries or disorders in the past 6 months.
- Individuals who have received antibiotic treatment or taken probiotic supplements in the past 6 months.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06670742 · NTSUIRB - 112 - 007