Recruiting NCT06669520
Correlation of Blood Serum Renalase and Microcirculation Obstruction in Patients with Acute Myocardial Infarction After Primary Percutaneous Coronary Intervention
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Acute Myocardial Infarction. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This research will explore the association between blood serum renalase and microcirculation obstruction in patients with acute myocardial infarction (AMI) after primary percutaneous coronary intervention (PCI). The investigators aim to identify potential risk factors for microcirculation obstruction in AMI patients after PPCI.
Primary outcome measures
- Number of Participants with Microvascular Obstruction Assessed by Contrast-Enhanced Magnetic Resonance Imaging 3-7 Days After Percutaneous Coronary Intervention. [Time frame: 3-7 days after PPCI]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years;
- STEMI symptom onset time < 12 hours;
- STEMI symptom onset time 12-48 hours with persistent ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias;
- High-risk NSTEMI;
- Emergency PCI;
- Voluntary informed consent.
Exclusion criteria
- Non-obstructive acute myocardial infarction;
- Severe chronic kidney disease (defined as estimated glomerular filtration rate < 20 mL/min per 1.73 m²);
- Life expectancy < 1 year;
- Pregnant or planning to become pregnant;
- Emergency PCI failure.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- The Third Xiangya Hospital of Central South University — Changsha
Publications
- Chen Y, Li R, Fu R, Zhao L, Sheng Z, Fu J, Xu K, Liu J, Huang W, Chen C, Wen J, Zeng L, Ou Z, Sun N, Jiang Z, Zhu C, Liu Y, Wang Y, Zhou H, Wang X, Jiang W, Li X. Periprocedural 24-Hour Change in Renalase Adds Incremental Value for Early Risk Stratification of Cardiovascular Magnetic Resonance-Defined Microvascular Obstruction in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing PMID 42432418
- Chen Y, Li R, Fu R, Zhao L, Sheng Z, Xu K, Liu J, Huang W, Wen J, Zeng L, Ou Z, Jiang Z, Liu Y, Wang Y, Jiang W, Li X. Association between periprocedural change in serum renalase and microvascular obstruction in patients with STEMI after primary percutaneous coronary intervention: protocol for the ReMVOS prospective cohort study. BMJ Open. 2025 Nov 28;15(11):e110045. doi: 10.1136/bmjopen-2025-1100 PMID 41314850
Identifiers
NCT: NCT06669520 · K 24655