PET-CT to Assess Brain Damage in Cardiac Arrest Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No interventions.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest, Brain Injuries. Basic parameters: 18 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Assessment of Cerebral Metabolism, Cerebral Blood Flow and Cerebral Oxygen Damage in Patients With Cardiac Arrest Using PET-CT
Overview
This was a single-center, observational study. Patients with successful cardiopulmonary resuscitation (CPR) will be transferred to the emergency intensive care unit for further standardized management. After successful return of spontaneous circulation (ROSC) for 72 hours and hemodynamic stability for 24 hours, the patients underwent positron emission computed tomography (PET-CT) examination after resuscitation. The supervising physician accompanied the patient and used monitors to monitor vital signs during the examination. Patients who were on ventilators were mechanically ventilated with a magnetic ventilator (HAMILTON-MRI, United States). In addition to conventional cerebral oxygen metabolism, cerebral blood flow, oxygen extraction fraction, cerebral blood volume and other indicators were added in this experiment. These indicators can evaluate the patient's cerebral metabolism, cerebral blood flow and cerebral blood oxygen damage degree. The neurological outcome was followed up 6 months after onset according to the cerebral performance category（CPC）.
Interventions
- Other No interventions
No interventions
Primary outcome measures
- Neurologic prognosis [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- age ≥18 years.
- sustained hemodynamic stability for ≥24h.
- the patients were unconscious and not able to obey verbal commands. • Advanced life support and target temperature management within 6 hours of return of spontaneous circulation (ROSC).
Exclusion criteria
- Patients with hemodynamic instability.
- Patients who could not complete cranial PET-CT examination for special reasons. • Patients during pregnancy.
- Patients who combined traumatic brain injury, stroke, cerebral hemorrhage and other diseases.
- Patients whose family members did not agree to be enrolled.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Beijing chaoyang hospital — Beijing
Identifiers
NCT: NCT06660238 · 2024-9-26-836