Clinical Classification and Imaging Markers in Patients of Obesity
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Naturalistic observation.
- Who it may be relevant to
- Registry conditions: Obesity, fMRI, Clinical Classification. Basic parameters: 20 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This is an observational study to explore the etiology and clinical classification in patients with obesity and to achieve personalized treatment.
Detailed description
In this project, individuals with obesity and control individuals were recruited and followed up every year. Clinical neuropsychological scores, olfactory function tests, and functional magnetic resonance imaging (fmri) were performed to describe the brain function characteristics under different odor stimulation in fasting and after eating, and to explore the pathogenesis and clinical classification of obese patients. The correlation analysis between imaging analysis values and clinical laboratory data, neuropsychological scores and olfactory behavior scores was performed to explore indicators related to cognitive decline and provide new insights into the etiology and classification of obese patients. Combined with clinical evaluation and imaging examination, the changes of cognitive behavior and brain structure and function in obese patients were followed up.
Interventions
- Other Naturalistic observation
Naturalistic observation
Primary outcome measures
- Brain imaging features in patients with obesity by fMRI [Time frame: From 2024 to 2028]
- Biomarkers of patients with obesity by blood sample [Time frame: From 2024 to 2028]
- Clinical classification of patients with obesity [Time frame: From 2024 to 2028]
- Prevention and intervention strategies for obesity based on clinical classification [Time frame: From 2024 to 2028]
Eligibility criteria
Inclusion criteria
- Patients with BMI≥28kg/m2
- Aged 18-65 years of both sexes, right-handed
- At least 6 years of education
- Patients agreed and signed the informed consent
Exclusion criteria
- Fewer than 6 years of education
- Left-handedness
- Dementia
- Acute metabolic complications such as diabetic ketoacidosis
- Hyperglycaemic hyperosmolar state and hypoglycaemic coma within the previous 3 months; history or presence of neurological or psychiatric disorders;
- Presence of hypothyroidism;
- History of malignancy, or severe kidney or liver dysfunction.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Department of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum — Nanjing
Identifiers
NCT: NCT06649071 · OB2024