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Recruiting NCT06646432

Treatment of Gingival Recession With Tunnel Technique Using Connective Tissue Graft and Injectable Platelet Rich Fibrin

No phase Interventional Gingival Recession

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Tunnel with connective tissue graft and injectable platelet rich fibrin, Tunnel with connective tissue graft only.
Who it may be relevant to
Registry conditions: Gingival Recession. Basic parameters: from 21 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Treatment of Gingival Recession by Tunnel Technique Using Connective Tissue Graft With or Without Injectable Platelet Rich Fibrin: A Randomized Controlled Clinical Trial

Overview

Gingival recession is a common periodontal problem. Consequences include teeth sensitivity, poor esthetics and impaired oral hygiene access. Mild cases are managed by optimizing oral hygiene measures, correction of any causative factor such as faulty tooth brushing, improper dental restoration or denture clasp. Prescription of desensitization products such as specific tooth gels or mouth washes can manage the sensitivity problem. Deeper recession defects need to be addressed by surgical procedures. Coronally advanced flap with connective tissue graft is the gold standard procedure. However, it has some drawbacks due to the need for papillary incisions and vertical incisions in some cases. Within the era of minimally invasive periodontology, tunnel technique with connective tissue graft showed results comparable to coronally advanced flap with connective tissue graft but with some limitations. Addition of another agent may enhance the results of tunnel technique. Injectable platelet rich fibrin is known for its content of growth factors and effects on soft tissue healing. Aim: The study aim is to compare the surgical management of gingival recession with tunnel technique using connective tissue graft and injectable platelet rich fibrin to tunnel with connective graft without injectable platelet rich fibrin. Methodology: 30 patients with miller class I or II gingival recession will be enrolled. 15 in the test group (Tunnel+ CTG+ i-PRF) and 15 in control group (Tunnel+ CTG). Clinical evaluation at 6 months

Detailed description

30 patients with miller class I/II gingival recession will be enrolled in this study.

15 patients will be treated using tunnel technique and palatal connective tissue graft inserted and sutured under the prepared tunnel after being soaked in injectable platelet rich fibrin for 15 minutes. The tunnel with the underlying graft will be advanced coronally. (Test Group) The other 15 patients will be treated the same way as in the first group but without soaking the graft in injectable platelet rich fibrin. (Control Group) Clinical parameters will be evaluated at baseline and 6 months follow-up except post-operative pain which will be assessed after 10 days. Histologic examination of small piece of the graft will be done to assess if there is true saturation of growth factors inside the graft.

Interventions

  • Procedure Tunnel with connective tissue graft and injectable platelet rich fibrin
    Tunnel with connective tissue graft and injectable platelet rich fibrin
  • Procedure Tunnel with connective tissue graft only
    Tunnel technique with connective tossue graft only without injectable platelet rich fibrin

Primary outcome measures

  • Recession depth [Time frame: 6 months after the surgery]
  • Keratinized tissue height [Time frame: 6 months]
  • Gingival thickness [Time frame: 6 months]
Secondary outcome measures (2)
  • Post operative pain [Time frame: 10 days]
  • Recession width [Time frame: 6 months]

Eligibility criteria

Inclusion criteria

  • More than 21 years old
  • Systemically healthy
  • Presence of Miller class I/II gingival recession
  • Presence of identifiable CEJ

Exclusion criteria

  • Smoking
  • Systemic disease that contraindicates surgical procedures.
  • Poor compliance with oral hygiene measures
  • Necrotizing gingival conditions
  • Ongoing active periodontitis

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Egypt · 1 center
  • Faculty of dentistry, Suez canal university — Ismailia

Publications

  • Mahmoud MNA, Elrefaei AMH, Shata MS, Rokaya D, Morsy SM. Connective tissue graft with injectable platelet rich fibrin for treatment of RT1 gingival recession by tunnel technique: a randomized clinical and immunohistochemical study. Front Oral Health. 2026 Jun 10;7:1801423. doi: 10.3389/froh.2026.1801423. eCollection 2026. PMID 42359019

Identifiers

NCT: NCT06646432 · 486/2022

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗