Obesity Doppler in Term Pregnancy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Doppler Measurement of Uterine Artery. Basic parameters: 20 years — 35 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Effect of Maternal Obesity on Umbilical and Uterine Artery Doppler in Term Pregnancy : a Cross-sectional Study
Overview
Maternal obesity is an epidemic in the developed world like Egypt. There are many pregnancy-associated complications including pre-eclampsia, gestational diabetes, and increased rates of septic wound after cesarean delivery. As a potential explanation of the etiology of complications due to maternal obesity, the role of endothelial dysfunction in the systemic and peripheral vasculatures has been hypothesized. It has been proposed that some adverse pregnancy outcomes in obese patients may be mediated by placental insufficiency. Utero-placental insufficiency is typically associated with fetal growth restriction and low birth weight. Umbilical and uterine artery Doppler is widely accepted as a useful tool for monitoring high-risk pregnancies. Normally, uterine artery vascular impedance gradually decreases until the late mid-trimester, owing to the establishment of a low-resistance placental circulation. Obesity has little impact on uterine vascular changes reflected by the early uterine artery PI. However, in the second trimester, extreme obesity appears to impair the normal continued drop in uterine vascular resistance. Many studies have examined the relationship between BMI and Doppler changes in high-risk pregnancies, but few have addressed these changes in low-risk pregnancies.
Primary outcome measures
- The difference between uterine and umbilical artery Doppler resistant index [Time frame: at 37 weeks of pregnancy]
Eligibility criteria
Inclusion criteria
- Singleton pregnancy
- Gestational age ≥ 37 weeks
- Absence of fetal structural abnormalities
- Absence of maternal comorbidities and/or complications.
- Obese women (BMI ≥ 30 kg/m2) \[11\].
- Normal weight (BMI 18.5-24.9) \[11\].
Exclusion criteria
- Placenta previa
- Women with antepartum hemorrhage.
- Smokers and alcohol consumers
- Preeclampsia
- Diabetes mellitus
- Women need urgent termination of pregnancy.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-crossover
Study locations
Egypt · 1 center
- Woman's Health Hospital - Assiut university — Asyut
Identifiers
NCT: NCT06644911 · Doppler-150