White Matter Plasticity in Schizophrenia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Music video game.
- Who it may be relevant to
- Registry conditions: Schizophrenia Disorders. Basic parameters: 15 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
Interventions
- Behavioral Music video game
The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'
Primary outcome measures
- White matter microstructure [Time frame: 3 weeks]
Secondary outcome measures (1)
- Brain level of N-acetylaspartate [Time frame: 3 weeks]
Eligibility criteria
Inclusion criteria
- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- age 15-45
- able to provide informed consent
Exclusion criteria
- contraindications to MRI (metal implants, claustrophobia)
- medical condition that limits use of hands (ie, arthritis)
- Active or recent (within 6 months) substance use disorder other than nicotine
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
United States · 2 centers
- Maryland Psychiatric Research Center — Catonsville
- University of Maryland Baltimore - Maryland Psychiatric Research Center — Catonsville
Identifiers
NCT: NCT06641297 · HP-00081020