Menu
Enrolling by invitation NCT06624254

Ventilator Mode and Respiratory Physiology

— Observational Pulmonary Disease Respiratory Failure Respiratory Effort Breathing Mechanics

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: lung mechanics, respiratory drive and effort.
Who it may be relevant to
Registry conditions: Pulmonary Disease, Respiratory Failure, Respiratory Effort, Breathing Mechanics. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

Interventions

  • Other lung mechanics, respiratory drive and effort
    Patient lung mechanics and respiratory drive and effort will be measured

Primary outcome measures

  • Excess tidal volume [Time frame: From enrollment to end of monitoring at 4 hours]

Eligibility criteria

Inclusion criteria

  • Admitted to ICU with acute respiratory failure
  • On adaptive pressure control mode of ventilation
  • Tidal volumes set between 5-8 cc/kg ideal body weight

Exclusion criteria

  • Current use of neuromuscular blockade
  • Inability to obtain consent from patient or surrogate decision maker
  • Treating clinician refusal

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

United States · 1 center
  • University of California San Diego Health — La Jolla

Identifiers

NCT: NCT06624254 · 807319

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗