Using Renal Elastography Measurements for Evaluation of Glomerulonephritis Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: renal shear wave elastography.
- Who it may be relevant to
- Registry conditions: Evaluation of Biopcy Proven Glomerulonephritis Patients by Renal Shear Wave Elastography. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
All participants will clinically evaluated by history taking, full physical examination including body weight and assessment of fluid status, and blood and urine samples for lab analysis (serum creatinine, urea, sodium, potassium, corrected calcium, phosphorous, estimated glomerular filtration rate(GFR) by Cokcroft equation ((140 - age ) x body weight by Kg/creatinine by µmol )complete urine analysis including microscopic examination of urine , 24 hours urinary protein , haemoglobin level . All participants will undergo renal shear wave elastography measurements. Values will be obtained from the upper, middle, and lower zones of each kidney. A total of six shear wave elastography measurements will be collected to get mean elastography values (MEVs) of each participant.
Detailed description
We will collect results of MEV plus blood and urine samples of each participant then data will undergo statistical analysis to compare between MEV of healthy persons and biopcy proven glomerulonephritis patients
Interventions
- Diagnostic test renal shear wave elastography
Renal shear wave elastography is a non-invasive ultrasound elastography technique that allows measurements of tissue stiffness. It provides real-time measurements of shear wave velocity (SWV) generated with an acoustic impulse, thereby providing quantitative information about tissue elasticity. Harder tissues have been shown to have higher SWV . Renal shear wave elastography will be done to both groups
Primary outcome measures
- comparisons between the shear wave elastography measurements in GN patients and healthy persons . [Time frame: One year]
Eligibility criteria
a-inclusion criteria :
- adult patients aged 18 years old or more
- patients diagnosed as glomerulonephritis ( biopcy proven ) and not started specific tratement in Assiut University Hospitals
b. Exclusion criteria:
- patient with urinary tract obstruction
- patient who has GN and started corticosteroid and/or immunosuppressive drugs
- patient who has congenital anomalies in renal system
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Egypt · 1 center
- Faculty of medicine,Assiut universty,Egypy — Asyut
Identifiers
NCT: NCT06623877 · 6121820722