The Effectiveness of Interventions Targeting Self-Perception of Aging in Older Adults with Subjective Cognitive Decline
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Multidomain Intervention Program.
- Who it may be relevant to
- Registry conditions: Subjective Cognitive Decline (SCD). Basic parameters: from 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Subjective cognitive decline (SCD) represents the initial clinical manifestation in the disease spectrum of Alzheimer's Disease (AD). It represents an essential stage for early prevention and treatment of cognitive impairment, making the SCD population an optimal target for prior intervention. This study aims to assess the feasibility and efficacy of an 8-week intervention targeting self-perception of aging in community-dwelling older adults with SCD.
Detailed description
Dementia, especially Alzheimer's Disease (AD), is a major healthcare issue in aging populations. It not only threatens the physical and mental health of older adults but also imposes significant economic and caregiving burdens on families and society. As a preclinical stage of AD, subjective cognitive decline (SCD) is regarded as the optimal phase for early intervention in cognitive impairment. When confronted with the threats of physical, psychological, and social aging, older adults with SCD often hold negative perceptions and emotional responses toward their own aging. They tend to attribute physical decline and memory loss to normal aging processes, overlooking controllable factors, which poses potential risks to their future cognitive outcomes, such as accelerated cognitive decline, elevated dementia risk, and increased accumulation of AD biomarkers. This study is based on the Transactional Model of Stress and Coping (TMSC) and identifies the mechanisms through which self-perception of aging influences cognitive function in older adults with SCD. A comprehensive 8-week intervention program was developed to target these mechanisms. The 8-week intervention program aims to provide practical evidence for delaying cognitive decline in older adults with SCD by enhancing their positive perceptions of aging.
Interventions
- Other Multidomain Intervention Program
The intervention program aims to help older adults with subjective cognitive decline understand the aging process and adopt a positive attitude toward aging, highlighting age-related benefits. The sessions also provide emotion regulation techniques and stress-coping strategies to encourage proactive problem-solving and build confidence in handling challenges. By recalling positive life experiences, the program seeks to strengthen emotional connections, enhance the sense of belonging, and reconst
Primary outcome measures
- Subjective Cognitive Decline [Time frame: Baseline (pre-intervention)，8 weeks (post-intervention)，and 16 weeks (follow-up)]
Secondary outcome measures (4)
- Cognitive Function [Time frame: Baseline (pre-intervention)，8 weeks (post-intervention)，and 16 weeks (follow-up)]
- Self-perception of Aging [Time frame: Baseline (pre-intervention)，8 weeks (post-intervention)，and 16 weeks (follow-up)]
- Perceived Stress [Time frame: Baseline (pre-intervention)，8 weeks (post-intervention)，and 16 weeks (follow-up)]
- Coping Strategies [Time frame: Baseline (pre-intervention)，8 weeks (post-intervention)，and 16 weeks (follow-up)]
Eligibility criteria
Inclusion criteria
- aged ≥60 years;
- residing in the community for 6 months at least;
- experiencing a consistent decline in self-reported cognitive abilities;
- having standard cognitive test performance in the normal range;
- willing to participate in this study.
Exclusion criteria
- having diagnosis of any neurological diseases including Parkinson's disease, brain tumor, cerebral infarction, encephalitis, epilepsy, etc.;
- having diagnosis of mental illness such as depression, anxiety, bipolar disorder, and schizophrenia;
- with history of substance abuse or addiction;
- with severe visual or hearing impairment.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Prevention
Study locations
China · 1 center
- School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College — Beijing
Identifiers
NCT: NCT06622889 · PUMCSON-2023-05