Effect of Endurance Training-Induced Coenzyme Q10 (CoQ10) Supplementation on Myokine, Exerkine Secretion and Cognitive Functions in Long-Distance Runners
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: CoQ10 supplementation, Placebo supplementation.
- Who it may be relevant to
- Registry conditions: Health Knowledge, Attitudes, Practice. Basic parameters: 30 years — 50 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The goal of this clinical trial is to learn if CoQ10 amplifies endurance training-induced myokine and exerkine secretion and if those changes influences cognition in long-distance runners. Does 4-week high-dosage CoQ10 supplementation increase the secretion of myokine, exerkine sercetion? Does the above-mentioned intervention improve the cognitive function in long distance runners? Participants will: Take CoQ10 or a placebo every day for 4 weeks. Visit the laboratory once every 4 weeks for checkups and tests. Keep the participants' food and training diary.
Interventions
- Dietary supplement CoQ10 supplementation
Long-distance runners will be supplemented with CoQ10 for 4 weeks in cross-over manner with 4 weeks of wash out period. - Dietary supplement Placebo supplementation
Long-distance runners will be supplemented with placebo for 4 weeks in cross-over manner with 4 weeks of wash out period.
Primary outcome measures
- Change in cognitive funtions as a result of CoQ10 supplementation measured via cogntitive function test. [Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10]
- Change in myokine and exerkine concentration in the blood plasma as a result of CoQ10 supplementation. [Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10]
Secondary outcome measures (1)
- Change in aerobic capacity measured via direct test to volitional exhaustion on a motorized treadmill [Time frame: The investigators are going to check this hypothesis after 4 weeks of high-dose supplementation with CoQ10]
Eligibility criteria
Inclusion criteria
- training experienced for minimum 2 years
- running training at least 2 times per week
- Personal Best on 10k (<50 minutes)
Exclusion criteria
- taking supplements which can interrupt primary outcomes (vitamin D, omega-3 fatty acids)
- injured in last 6 months to avoid n number reduction
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
Poland · 1 center
- Gdansk University of Physical Education and Sport — Gdansk
Identifiers
NCT: NCT06619249 · AWFiS/2024_3_ZJ