Sevoflurane Sedation as an Alternative for Awake Fiberoptic Intubation in Difficult Airway Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Sevoflurane, 2% Xylocaine (2 ml ).
- Who it may be relevant to
- Registry conditions: Sevoflurane, Sedation, Awake Fiberoptic Intubation, Difficult Airway. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The aim of this study is to compare patient satisfaction and intubating conditions with fiber optic intubation under sevoflurane sedation versus airway blocks in difficult airway patients
Detailed description
Awake fiberoptic intubation (AFOI) is a suitable option for anticipated difficult intubation. The ideal condition for AFOI requires a calm, cooperative patient with blunted airway reflexes to facilitate easy intubation, especially if there is difficulty with laryngeal anatomy and/or pathology.
For this purpose, sedative and anxiolytic agents such as benzodiazepines, sevoflurane, remifentanil, ketamine, propofol, and dexmedetomidine are almost always required to relieve the patients from comfort without impairing ventilation. Patient responsiveness and cooperation are almost always required.
Interventions
- Drug Sevoflurane
Patients will undergo fiberoptic intubation under sevoflurane sedation. - Drug 2% Xylocaine (2 ml )
Patients will undergo fiberoptic intubation with bilateral Superior Laryngeal Nerve block and Recurrent laryngeal nerve block.
Primary outcome measures
- Degree of patient satisfaction [Time frame: Immediately after intubation]
Secondary outcome measures (5)
- Intubation time [Time frame: Intraoperatively]
- Heart rate [Time frame: 5 minutes after intubation]
- Mean arterial pressure [Time frame: 5 minutes after intubation]
- Patient's tolerance to endoscopy [Time frame: Intraoperatively]
- Patient's tolerance to intubation [Time frame: Intraoperatively]
Eligibility criteria
Inclusion criteria
- Age from 18 to 50 years.
- Both sexes.
- American Society of Anesthesiology (ASA) physical status I-II.
- Patients with difficult airway (Mallampati grade 3 and 4 with mouth opening less than 5 cm).
Exclusion criteria
- Patient refusal.
- Patients with bleeding disorders and nasal mass.
- Allergy or intolerance to one of the study medications.
- Patients with uncontrolled systemic diseases.
- patients with gastro-esophageal reflex.
- history of nasopharyngeal surgery or drug abuse.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Egypt · 1 center
- Tanta University — Tanta
Identifiers
NCT: NCT06601036 · 36264PR591/3/24