Loss of Y Chromosome in Aortic Stenosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood analysis for loss-of-Y chromosome.
- Who it may be relevant to
- Registry conditions: Aortic Stenosis. Basic parameters: from 40 years · Male.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
Interventions
- Diagnostic test Blood analysis for loss-of-Y chromosome
Analysis for the percentage of circulating leukocytes with loss-of-y chromosome
Primary outcome measures
- Loss of Y chromosome [Time frame: 1 day]
Eligibility criteria
Inclusion criteria
- Aortic stenosis (valve area \<1.5cm2)
Exclusion criteria
- Bicuspid aortic valve
- History of radiation to chest
- Inflammatory (autoimmune, rheumatologic) disease associated with aortic stenosis
- Active cancer
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- University of Virginia — Charlottesville
Identifiers
NCT: NCT06595407 · 301597