Eating Disorders Genetics Initiative 2
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Eating disorder diagnosis group.
- Who it may be relevant to
- Registry conditions: Anorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Avoidant Restrictive Food Intake Disorder. Basic parameters: 12 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States, Australia, Mexico, New Zealand, Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The overarching intention of the Eating Disorder Genetics Initiative 2 (EDGI2) is to increase sample size, diversity, and eating disorder phenotypes. The investigators are enrolling 20,000 new participants with anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), avoidant/restrictive food intake disorder (ARFID), and controls in the US, Mexico, Australia, New Zealand, Sweden, and Denmark. A primary study goal is to enroll at least 30% of participants from underrepresented groups. Participants are asked to complete a series of questionnaires and submit a saliva sample for genotyping. The goal is to better understand eating disorders and how they relate to each other so that better treatments can be developed.
Interventions
- Other Eating disorder diagnosis group
This is an observational study, no active intervention is applied. Participants are assigned to an eating disorder diagnosis group based on their lifetime history of disordered eating behaviors and symptoms.
Primary outcome measures
- Number of Participants Identified with an Eating Disorder Diagnosis by Category [Time frame: Baseline]
- Age of eating disorder onset [Time frame: Baseline]
Secondary outcome measures (9)
- Current Disordered Eating Symptoms [Time frame: Baseline]
- Mental Health and Behavior [Time frame: Baseline]
- Mood - Lifetime history of mood and anxiety disorders [Time frame: Baseline]
- Self-Violence [Time frame: Baseline]
- Lifetime Substance Use [Time frame: Baseline]
- Life-Events [Time frame: Baseline]
- Eating Disorder Quality of Life [Time frame: Baseline]
- Compulsive Exercise Test [Time frame: Baseline]
- Perfectionism [Time frame: Baseline]
Eligibility criteria
Inclusion criteria
- A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms
- Age 12-99 years, depending on country. (US enrollment age is 18-99)
Exclusion criteria
- History of subthreshold disordered eating behaviors.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- University of North Carolina at Chapel Hill — Chapel Hill
Australia · 1 center
- QIMR Berghofer — Brisbane
Mexico · 1 center
- Comenzar de Nuevo — Monterrey
New Zealand · 1 center
- University of Otago — Christchurch
Sweden · 1 center
- Karolinska Institutet — Stockholm
Publications
- Berthold N, MacDermod CM, Thornton LM, Parker R, Morales SAC, Hog L, Kennedy HL, Guintivano J, Sullivan PF, Crowley JJ, Johnson JS, Birgegard A, Fundin BT, Frans E, Xu J, Ngati Pukenga MP, Miller AL, Aguilar MV, Barakat S, Abdulkadir M, White JP, Larsen JT, Trujillo E, Winterman B, Zhang R, Lawson R, Wonderlich S, Wonderlich J, Schaefer LM, Mehler PS, Oakes J, Foster M, Gaudiani J, Vacuan ETC, Com PMID 40419993
Identifiers
NCT: NCT06594913 · 23-2887 · R01MH136149 · R01MH136157 · R01MH136156