Strength Training and Resveratrol
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Resistance training, Resveratrol 500 mg oral once daily., Placebo.
- Who it may be relevant to
- Registry conditions: Sarcopenia, Anabolic Resistance. Basic parameters: from 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Resveratrol-mediated Changes in Extracellular Vesicle microRNA Cargo as a Novel Contributor to Resistance Training-induced Skeletal Muscle Adaptations in Older Adults
Overview
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.
Detailed description
After screening and providing informed consent, participants (healthy older adults, age 60+, minimally active) will be familiarized with the procedures and undergo pre-testing. After pre-testing, participants will be assigned to supplement with resveratrol or placebo (double-blinded) daily while undergoing a strength training intervention. Strength training will be performed 3x/week for two 6-week blocks, and each visit will be supervised by a member of the study team. An additional week of testing will follow each of the two 6-week blocks.
Interventions
- Behavioral Resistance training
After pre-testing, participants will perform full-body strength training three times per week for two 6-week blocks. The acute program variables (sets, repetitions, training frequency) will follow a non-linear periodized, progressive design consisting of muti-joint and single-joint exercises. Exercise stress will be varied by using different exercises and loads. The two training blocks will be separated by a mid-intervention testing week, allowing for the study team to monitor participants' prog - Dietary supplement Resveratrol 500 mg oral once daily.
Participants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored. - Dietary supplement Placebo
Participants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
Primary outcome measures
- Circulating extracellular vesicle microRNA profile [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Muscle torque [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Muscle fatigability [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Muscle strength [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Appendicular skeletal muscle mass index [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
Secondary outcome measures (6)
- Waist-to-hip ratio [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Vascular function [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Cognitive function [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Grip strength [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Lower body strength/endurance [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
- Gait speed [Time frame: During pre-, mid-, and post-testing (each separated by about 6 weeks)]
Eligibility criteria
Inclusion criteria
- Age 60+
- Minimally active (less than 1 hour of structured exercise/week other than walking)
- No resistance training for the previous 6 months
- Not currently taking resveratrol supplements
- Stable medication, supplement, dietary, and physical activity regimens for the previous 3 months and no plans to change throughout the study period
- Body mass at least 110 lbs
Exclusion criteria
- Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
- Cannabis or nicotine use
- Consume more than 7 alcohol-containing beverages per week
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Triple blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Department of Kinesiology & Sport Management, Texas Tech University — Lubbock
Identifiers
NCT: NCT06585865 · YI-2024-02 · IRB 2024-587