Pancreatic Cancer and Diabetes Mellitus
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data..
- Who it may be relevant to
- Registry conditions: Pancreatic Cancer, Surgery, Diabetes Mellitus. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Cohort Study on Endo-Exdo Secretory Function Alterations and All-round Outcomes After Pancreatic Cancer
Overview
The goal of this observational study is to learn about post-surgery of pancreatic cancer diabetes mellitus.The main questions it aims to answer are: 1. Are the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) after pancreatic cancer of different etiologies the same? 2. Are alterations in endocrine and exdocrine secretory function in patients with pancreatic surgery associated with all-round outcomes? All patients with pancreatic surgery have been given the standardized treatment for the condition. The reasearchers will summarize the incident rates of glucose metabolic disorders (pre-diabetes and diabetes mellitus) during different surgical procedures to explore the association between alternations in endocrine and exdocrine secrectory function and all-round outcomes.
Detailed description
Investigators will prospectively collect data from patients with pancreatic cancer after surgery in participant centers.
Interventions
- Diagnostic test All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.
All enrolled subjects completed dynamic blood glucose monitoring to obtain continuous peripheral blood glucose data.
Primary outcome measures
- Number of Participants Who developed glucose metabolic disorders(pre-diabetes and diabetes mellitus) [Time frame: From enrollment to five years after the end of the surgery]
Secondary outcome measures (2)
- Overall Survival [Time frame: From enrollment to five years after the end of the surgery]
- Disease-Free Survival [Time frame: From enrollment to five years after the end of the surgery]
Eligibility criteria
Inclusion criteria
1\. male or female Chinese subjects; 2. Age ≥ 18 years; 3. patients with pancreatic cancer who are proposed to undergo pancreatectomy by pancreaticobiliary surgery at our hospital; 4. those who voluntarily completed the Pancreatobiliary Surgery Cohort Study and signed the informed consent; 5. those who have completed and banked serum and pathological specimens at our hospital.
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Exclusion criteria
1\. those with a previous history of comorbid diabetes mellitus or pre-diabetes mellitus, or preoperative HbA1C ≥ 6.0% or fasting blood glucose ≥ 6.1 mmol/l; 2. those with positive islet-associated antibodies 3. those with the presence of medications, endocrine disease exposures that can lead to a risk of secondary diabetes; 4. pregnant or nursing women; 5. Cognitive impairment or other reasons for failing to sign the informed consent form.
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Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Changzheng Hospital — Shanghai
Identifiers
NCT: NCT06585072 · NMU-3CDM-2B