DNA Methylation Trajectories in Aging
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: RRBS.
- Who it may be relevant to
- Registry conditions: Heart Failure, Aging. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
EPIGENETIC-SENSITIVE BIOMARKERS OF INFLAMMAGING FROM HEALTHY TO HEART FAILURE DISEASE
Overview
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
Interventions
- Other RRBS
Measure of genomic regions with differentially methylated profiles and differentially expressed protein
Primary outcome measures
- Number of differentially methylated positions and regions as assessed by RRBS [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Healthy subjects aged between 18 and 40 years
- Aged subjects (≥65) without signs and symptoms of heart failure
- Aged subjects (≥65) with diagnosis of heart failure with preserved ejection fraction (EF major than 50%)
Exclusion criteria
- Heart failure with reduced ejection fraction (EF minor than 40%)
- Heart failure with mildly reduced EF (HFmrEF) (EF 41-49%)
- History or diagnosis of cancer and inflammatory diseases
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Italy · 1 center
- University of Campania Luigi Vanvitelli — Naples
Identifiers
NCT: NCT06582992 · Aging Well in an Aging Society