Menu
Not yet recruiting NCT06581172

Significance of Disseminated Intravascular Coagulation Score in Mortality for Children With Shock

— Observational Shock, Septic

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: D_dimer.
Who it may be relevant to
Registry conditions: Shock, Septic. Basic parameters: 1 year — 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC

Detailed description

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by excessive systemic activation of coagulation, resulting in both hemorrhage and thrombosis. DIC can progress rapidly into lifethreatening multiorgan failure. Under normal hemostatic conditions, clot formation and resolution are tightly regulated. In DIC, dysregulated activation of the coagulation system results in a consumptive coagulopathy and microvascular thrombosis. DIC is always a secondary process caused by a variety of underlying disorders (eg, sepsis, trauma, or malignancy), which can cause endothelial tissue damage and procoagulant exposure .

This activates the coagulation cascade, which promotes fibrin production and deposition and consumption of clotting factors. The subsequent consumption of coagulation factors and platelets, inhibition of natural anticoagulants and fibrinolysis, and fibrin deposition result in the clinical picture of DIC: a bleeding diathesis accompanied by microvascular thrombosis that often leads to end-organ damage . The International Society of Thrombosis and Hemostasis and the Japanese Association for Acute Medicine scoring systems are useful for detection of the DIC in critically ill pediatric patients . The overall incidence of DIC to be 1.2%, using a scoring system comprised of etiologic factors, clinical features, platelet count, prothrombin time, fibrinogen, and fibrin degradation products (FDPs) . The DIC score, easily computed in real-time at the bedside with routine laboratory values, is associated with mortality for children with sepsis andshock.

Diagnosis of DIC through test of the D-dimer. Accordingly, testing for Ddimer or FDPs may be helpful for evulating relationship between DIC score and mortality rate among children with shock .

Interventions

  • Diagnostic test D_dimer
    DIC score including FDPs,D\_dimer

Primary outcome measures

  • Evaluates whether the DIC score, as defined according to the International Society of Thrombosis and Hemostasis guidelines is associated with mortality in Children with shock and DIC [Time frame: Baseline]
  • Scoring system [Time frame: Baseline]
Secondary outcome measures (1)
  • Sample size [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

  • All Children with shock and DIC will developed during the period from 1-1-2025 to 31-12-2025

Exclusion criteria

  • Any shock not complicated with DIC

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Study design

Observational model
Other

Study locations

Center list to be confirmed — check the primary protocol.

Publications

  • Chanthong S, Choed-Amphai C, Manowong S, Tuntivate P, Tansriratanawong S, Makonkawkeyoon K, Natesirinilkul R. Rotational Thromboelastometry and Clot Waveform Analysis as Point-of-Care Tests for Diagnosis of Disseminated Intravascular Coagulation in Critically Ill Children in Thailand. Pediatr Crit Care Med. 2024 May 1;25(5):e221-e231. doi: 10.1097/PCC.0000000000003452. Epub 2024 Feb 1. PMID 38299935
  • Infante, J. B., Esteves, G. V., Raposo, J., & de Lacerda, J. F. (2024)
  • Kim, T. W., Ko, R. E., Choi, K. H., Chung, C. R., Cho, Y. H., & Yang, J. H. (2024)
  • Zafar A, Naeem F, Khalid MZ, Awan S, Riaz MM, Mahmood SBZ. Comparison of five different disseminated intravascular coagulation criteria in predicting mortality in patients with sepsis. PLoS One. 2024 Mar 7;19(3):e0295050. doi: 10.1371/journal.pone.0295050. eCollection 2024. PMID 38452037
  • Rashad, A. B., Habib, M. S., Saleh, N. Y., & Abo El Fotoh, W. M. (2023)
  • Songthawee N, Chavananon S, Sripornsawan P, McNeil E, Chotsampancharoen T. Prevalence and risk factors of disseminated intravascular coagulation in childhood acute lymphoblastic leukemia. Pediatr Res. 2023 Aug;94(2):588-593. doi: 10.1038/s41390-023-02475-8. Epub 2023 Jan 20. PMID 36670158
  • Zhang, R., Huang, H., Lu, S., Chen, J., Pi, D., Dang, H., ... & Fu, Y. Q. (2024).
  • Park, S. J., Oh, S. H., & Jhang, W. K. (2023, November).

Identifiers

NCT: NCT06581172 · DIC

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗