Evaluating Replacement of Standard-of-care Low Dose Computer Tomography (CT) Scans With Radiation-free Bone Imaging by Deep-learning Augmented Zero Echo Time (DL-ZTE) Magnetic Resonance Tomography (MRT)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Low Dose Computer Tomography.
- Who it may be relevant to
- Registry conditions: Joint Diseases, Joint Inflammation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Single-center Prospective Comparison of Diagnostic Performance of Deep-learning Agumented UTE/ZTE MRI Sequences and Standard-of-care Low Dose CT for Rheumatologic Patients With Musculoskeletal Disease
Overview
The goal of this clinical trial is to determine how effectively bone structures of the human skeleton can be visualized using Deep Learning (DL) augmented Magnetic Resonance Imaging (MRI) in individuals with inflammatory and degenerative joint changes, compared to Computed Tomography (CT). MRI is a technique that operates without the use of X-rays. The main question it aims to answer is: 1. Can DL MRI accurately depict bone structures as well as CT? 2. Can DL MRI be used as an alternative to CT to avoid exposure to X-rays in the future? Researchers will compare DL MRI scans to CT scans to see if DL MRI can effectively replace CT in visualizing bone structures without the use of radiation. Participants will: 1. Undergo MRI scans of their skeletal system that will then be processed using DL. 2. Undergo CT scans of the same body region for comparison purposes.
Interventions
- Radiation Low Dose Computer Tomography
Participants will undergo MRI scans of their skeletal system, followed by the Intervention of a Low Dose CT scan of the same body region for comparison purposes.
Primary outcome measures
- Total score for bone erosions [Time frame: one day (day of MRI and CT examination)]
- Total score for joint space narrowing [Time frame: one day (day of MRI and CT examination)]
- Visibility of cortical bone [Time frame: one day (day of MRI and CT examination)]
- Visibility of trabecular bone [Time frame: one day (day of MRI and CT examination)]
- Visibility of soft tissue calcifications [Time frame: one day (day of MRI and CT examination)]
- Contrast to noise ratio [Time frame: one day (day of MRI and CT examination)]
- Signal to noise ratio [Time frame: one day (day of MRI and CT examination)]
Eligibility criteria
Inclusion criteria
- Referral for a clinically indicated MRI examination of the musculoskeletal system to assess inflammatory and degenerative joint changes.
- Willingness to sign the informed consent form.
- No contraindications for a CT examination (e.g., claustrophobia).
Exclusion criteria
- No signed informed consent form.
- Patients under 18 years of age.
- Pregnant women.
- The calculated effective dose of the CT examination exceeds 5 mSv.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Single blind
- Primary purpose
- Diagnostic
Study locations
Switzerland · 1 center
- University Hospital Zurich — Zurich
Identifiers
NCT: NCT06579547 · DLZTECT