Evaluation of Intermittent Triple Therapies in Real Life
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: HIV Infections. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The strategy of intermittent triple therapy for people living with HIV was validated in France following the randomized clinical trial QUATUOR. There is little data in real life, as shown in the meta-analysis of Parienti JJ et al. Currently this strategy is proposed by some teams in France, but is not recommended internationally. The research hypothesis is that intermittent treatment is an effective and safe option in a therapeutic lightening strategy in people living with HIV People living with HIV adults followed in Strasbourg who have benefited from intermittent treatment The expected results will consist of an improvement in knowledge on the efficacy and tolerance of this therapeutic strategy.
Primary outcome measures
- Evaluation of HIV viral load [Time frame: 48 weeks after reduction of the HIV viral load]
Eligibility criteria
Inclusion criteria
- Adult subject (≥ 18 years old)
- Living with HIV monitored at the Trait d'Union/Infectious Diseases department in Strasbourg
- Having benefited from intermittent triple therapy between 01/01/2017 and 31/01/2024
Exclusion criteria
- Subject (and/or their legal representative if applicable) having expressed their opposition to the reuse of their data for scientific research purposes.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- Service Le Trait d'Union - CHU de Strasbourg - France — Strasbourg
Identifiers
NCT: NCT06578702 · 9238