Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Second alkaline phosphatase measurement.
- Who it may be relevant to
- Registry conditions: Hypophosphatasia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Germany
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The COHIR Multi-center Study - a Non-interventional, Prospective, Multi-center Investigation With Exploratory Data Analysis to Assess the Proportion of Patients With Hypophosphatasia Presenting at the Department of Rheumatology and Establishment of an Algorithm to HPP Diagnosis.
Overview
Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis
Detailed description
Acronym: Expansion:
HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase
Interventions
- Diagnostic test Second alkaline phosphatase measurement
(1-4 weeks after the 1st measurement)
Primary outcome measures
- Prevalence of hypophosphatasia in adult patients in rheumatology [Time frame: 36 months]
Eligibility criteria
Inclusion criteria
- Written informed consent
- Age > 18 years
- Clinical suspicion of hypophosphatasia
- Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening
Exclusion criteria
- Failure to meet the inclusion criteria listed above
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Germany · 1 center
- Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Cli — Bonn
Identifiers
NCT: NCT06574282 · MED2-202002