The Effect of Active Exercise on Maintenance Haemodialysis Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: exercise.
- Who it may be relevant to
- Registry conditions: Renal Dialysis. Basic parameters: 18 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Active Exercise on Nutritional and Inflammatory Status, Muscle Metabolism and Cardiovascular Events in Maintenance Haemodialysis Patients
Overview
The goal of this clinical trial is to discuss the effects of physical activity on nutrition, inflammation, muscle metabolism, and the occurrence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis. The main question it aims to answer is: can exercise improve nutritional and inflammatory status, enhance muscle strength, and reduce the incidence of cardiovascular and cerebrovascular events in patients with maintenance haemodialysis. Researchers will compared active exercise group to conventional treatment group to see the impact of exercise on maintenance haemodialysis patients. Participants will: Choose low-intensity aerobic exercise workouts such as walking (no less than 8,000 steps per day) or jogging, swimming, Tai Chi, etc., according to their individual conditions, for no less than 30 minutes at a time, at least 3 times per week, and the intensity of the exercise should be based on an RPE score of 12 to 16.
Detailed description
RPE: Rating of Perceived Exertion. RPE scores of 12 to 16 indicate the need for increased respiratory rate and depth during exercise, the ability to engage in conversational exchanges, light sweating, and a feeling of slight fatigue without reaching a state of exhaustion.
Interventions
- Behavioral exercise
such as walking, jogging, swimming, Tai Chi, etc. It needs to be at a certain frequency and intensity
Primary outcome measures
- Mid-upper arm circumference of the non-internal fistula side（AC） [Time frame: Baseline and half year, 1 year]
- triceps skin-fold thickness of the non-internal fistula side（TSF） [Time frame: Baseline and half year, 1 year]
- upper arm muscle circumference of the non-internal fistula side（AMC） [Time frame: Baseline and half year, 1 year]
- calf circumference [Time frame: Baseline and half year, 1 year]
- grip strength [Time frame: Baseline and half year, 1 year]
- Incidence of cardiovascular and cerebrovascular events [Time frame: 1 year]
Secondary outcome measures (5)
- prealbumin [Time frame: Baseline and half year, 1 year]
- albumin [Time frame: Baseline and half year, 1 year]
- haemoglobin [Time frame: Baseline and half year, 1 year]
- blood lipids [Time frame: Baseline and half year, 1 year]
- c-reactive protein [Time frame: Baseline and half year, 1 year]
Eligibility criteria
Inclusion criteria
- MHD more than 3 months, 3 times per week, 3-4h each time;
- Urea clearance index (Kt/V) >1.2;
- Stable condition, no serious infection, tumour and cardiovascular disease;
- Willing to join the study and sign the informed consent form.
Exclusion criteria
- Combined with serious heart and lung disease: such as repeated heart failure, severe arrhythmia, unstable angina pectoris, severe pericardial effusion, severe heart valve disease, hypertrophic cardiomyopathy, aortic coarctation, severe emphysema, pulmonary heart disease, severe pulmonary hypertension (average pressure of the pulmonary artery > 55mmHg), etc.;
- Combined with chronic joints, muscles, or vascular disease can not be or is not suitable for regular exercise, such as cerebrovascular disease; combined chronic joint, muscle or vascular disease can not or are not suitable for regular exercise, such as cerebrovascular disease sequelae, serious lower limb joint damage, severe myopathy, deep vein thrombosis, etc.;
- unwilling to cooperate with the movement of people
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
China · 1 center
- The First Affiliated Hospital of Chongqing Medical University — Chongqing
Identifiers
NCT: NCT06568835 · First ChongQing MU