CorEvitas International Adolescent Alopecia Areata (AA) Drug Safety and Effectiveness Registry
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Alopecia Areata. Basic parameters: 12 years — 17 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Prospective observational registry focusing on an adolescent cohort diagnosed with severe alopecia areata,receiving routine care from dermatology providers. Visit schedules for patients will be determined by the provider in accordance with routine clinical care, and any prescriptions provided to patients will adhere to product availability and local prescribing guidelines/regulations in the country where the participating registry site is located.
Detailed description
The objective of the registry is to create a cohort of adolescent subjects to evaluate the long-term real-world safety and effectiveness of routine clinical care of treatments for severe AA. Data collected through the registry may be used to address a range of research questions and use cases including, but not limited to: better characterizing the natural history of the disease, evaluating the effectiveness and safety of commercially available medications for the treatment of severe AA in adolescents, providing information to support characterization of adolescent growth and development and ongoing risk-benefit evaluation by drug manufacturers and regulators, and research related to drug utilization, disease burden, and unmet needs. Further, data collected may be used to generate real world evidence to inform clinical decision making by patients and treating providers.
This will be enabled through standardized data collection including validated instruments for patient-reported outcomes (PROs) and clinician-reported outcomes (ClinROs), the active evaluation of prevalent and incident comorbidities and adverse events, and the recording of medication utilization data.
Primary outcome measures
- AA epidemiology, presentation, natural history, management, and outcomes [Time frame: Through Study completion until the subject is 18 years]
Secondary outcome measures (12)
- Percentage of patients with history of comorbidities [Time frame: at registry enrollment]
- Patient reported : Hair Concealment Question [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Stressful Life Event [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Scalp Hair Assessment [Time frame: every 6 months until the subject is 18 years]
- Patient reported :Measures for Eye Irritation & Nail Appearance [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Numerical Rating Scale for Nasal irritation [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Alopecia Areata Patient Priority Outcomes (AAPPO) [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Patient Health Questionnaire (PHQ) [Time frame: every 6 months until the subject is 18 years]
- Patient reported :PROMIS Pediatric Sleep Disturbance 4 a [Time frame: every 6 months until the subject is 18 years]
- Patient reported : PROMIS Pediatric Stigma 8a [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Grief Assessment [Time frame: every 6 months until the subject is 18 years]
- Patient reported : Pubertal Tanner Staging [Time frame: every 6 months until the subject is 18 years]
Eligibility criteria
Inclusion criteria
To be eligible to participate in this registry, an individual must meet all the following criteria:
- Has ever been diagnosed with severe AA by a dermatologist or a qualified dermatology provider.
- Is 12-17 years of age at the time of enrollment.
- Is willing to provide consent/assent for participation in the registry.
- Has been prescribed a new commercially available advanced therapy and/or conventional systemic therapy for the treatment of severe AA in adolescents in the context of routine clinical care that is consistent with local prescribing guidelines and/or regulations for the country where the site is located.
A new therapy is a medication that the subject has never taken before.
- At the time of registry enrollment OR
- Within 6 months prior to registry enrollment In the opinion of the treating provider, is deemed a candidate for treatment with a commercially available advanced therapy and/or conventional systemic therapy for the treatment of severe AA in adolescents but has not received nor is planning to initiate treatment at the time of registry enrollment.
Exclusion criteria
An individual who meets any of the following criteria will be excluded from participation in the registry:
- Is participating or planning to participate in a blinded clinical trial for any investigational medication.
- Is unwilling or unable to provide standing height measurements.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- CorEvitas, LLC — Waltham
Identifiers
NCT: NCT06562270 · CorEvitas-AA-565