Standard Oxytocin Versus High Dose Oxytocin to Control Postpartum Hemorrhage in High Risk Pregnancy During Elective Cesarean Section
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Oxytocin.
- Who it may be relevant to
- Registry conditions: Post Partum Hemorrhage. Basic parameters: 20 years — 45 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Controlling hemorrhage during and after a cesarean section reduces significantly maternal mortality and morbidity and the present study is important for detection of the effectiveness of routinely increasing the oxytocin dose instead of using the standard dose only in preventing postpartum hemorrhage and additional use of uterotonics in the first 24 hours after cesarean section for high risk pregnancy.
Interventions
- Drug Oxytocin
will receive 10 IU oxytocin intravenous bolus over one min and infusion of 10 IU oxytocin in 500 ml of 0.9 saline over four hours.
Primary outcome measures
- blood loss [Time frame: at the end of the operation]
Secondary outcome measures (2)
- haemoglobin [Time frame: immediate preoperative]
- haemoglobin [Time frame: 6 hours postoperative]
Eligibility criteria
Inclusion criteria
- \- Medical disorders ie: Hypertensive diseases with pregnancy - Diabetes Mellitus - Collagen diseases - Coagulopathies - Cardiac diseases - Anemia
- History of postpartum hemorrhage
- Placental disorders ie: placenta previa
- Infertility and ICSI
- High Parity
- History of Endometriosis
- Fetal disorders (IUGR, IUFD, Preterm, Congenital anomalies, oligohydramnios or polyhydramnios, macrosomia)
- Preterm labor on uterine relaxants
- Twins pregnancy
- Patients on antiplatelets and anticoagulants
- Uneventful antenatal care
Exclusion criteria
- \- Oxytocin Allergy
- Normal uncomplicated pregnancy
- Emergency cesarean section
- Exhausted uterus due to trial of normal labor
- Couvelaire uterus
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Prevention
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06560099 · Laura 1 protocol