Analysis of Protein Expression in Serum of KOA Subjects
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Micro-Western Array.
- Who it may be relevant to
- Registry conditions: Knee Osteoarthritis. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Taiwan
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Analysis of Protein Expression in Serum of Subjects With Knee Arthritis Control Group and Evaluation by Meridian and Pulse Wave Energy
Overview
In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.
Interventions
- Device Micro-Western Array
The subjects first took the energy measurement of the pulse sphygmograph and Ryodoraku, rested for 20 minutes, and then repeated the measurements again. In order to comply with the acupuncture treatment course was 5 weeks in the previous study, we have two blood draw point. Each subject's blood was drawn for the first time, and then for the second time in 5 weeks later. Each subject drew 10ml of blood each time. The blood samples are analyzed by Micro-Western Array (MWA) and Enzyme-linked immuno
Primary outcome measures
- Micro-Western Array and Enzyme-linked immunosorbent assay [Time frame: the first and the fifth weeks]
Secondary outcome measures (1)
- pulse sphygmograph and Ryodoraku [Time frame: the first and the fifth weeks]
Eligibility criteria
Inclusion criteria
- Adults over 50 years old without knee pain
Exclusion criteria
- Clinical diagnosis of knee osteoarthritis
- Taking anti-inflammatory and analgesic drugs in the past month
- Taking blood-lipid-lowering drugs or health foods in the past month
- Received any acupuncture treatment in the past 3 weeks
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Taiwan · 1 center
- China Medical University — Taichung
Identifiers
NCT: NCT06553313 · CMUH113-REC3-115