Evaluation of the Effect of Central Sensitivity on Pain and Functional Status After Total Knee Joint Replacement Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Total knee arthroplasty.
- Who it may be relevant to
- Registry conditions: Central Sensitisation, Postoperative Pain, Arthritis. Basic parameters: 60 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The study is a prospective observational study designed to determine the effects of central sensitization on pain and functional status of patients before and after total knee joint replacement surgery. The aim of this study is to evaluate whether there is a difference in preoperative and postoperative pain and functional status between patients with and without central sensitization with knee osteoarthritis. When the literature was reviewed, it was seen that central sensitization was one of the important mechanisms that caused pain in knee osteoarthritis, and it was determined that this had negative consequences in terms of postoperative pain and improvement in functional status. In this study, the effect of central sensitization on the results will be investigated by evaluating pain and functional status before and after knee total joint prosthesis in two groups of knee osteoarthritis patients, with and without central sensitization, and by comparing the groups.
Interventions
- Procedure Total knee arthroplasty
Patients already admitted for total knee arthroplasty for knee osteoarthritis will have the procedure as planned
Primary outcome measures
- Knee pain [Time frame: Preoperative, 1 month postoperative and 3 months postoperative]
Secondary outcome measures (1)
- Functional Status [Time frame: Preoperative, 1 month postoperative and 3 months postoperative]
Eligibility criteria
Inclusion criteria
- Diagnosis of primary knee osteoarthritis
- Planning for total joint replacement surgery for the knee
- Being between the ages of 60-75
Exclusion criteria
- Having secondary knee osteoarthritis
- Planning for knee total joint prosthesis revision
- Having uncontrolled systemic disease (such as diabetes mellitus, hypertension, thyroid disease)
- Having neuromuscular disease
- Having a body mass index over 40
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT06553118 · 2024/1010