Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Carbon Monoxide Poisoning. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury. This study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning
Detailed description
This is a single-center retrospective study on health data. The methodology includes a collection of data on health and history data of patients treated by HBOT fo CO poisoning between 01/01/2015 and 31/12/2021 and carrying out a telephone interview of patients who have had early cardiovascular manifestations of CO poisoning.
One month between the start of theses interviews, an information letter on the study is sent by post, giving the possibility of opposing it.
Primary outcome measures
- early and late cardiac injury due to CO poisoning description [Time frame: enrollment (inclusion)]
Secondary outcome measures (5)
- relationship between the source of CO poisoning and cardiac injury [Time frame: enrollment (inclusion)]
- relationship between context of poisoning (domestic, professionnal or intentional poisoning) and cardiac injury [Time frame: enrollment (inclusion)]
- relationship between other possibly associated poisoning and cardiac injury [Time frame: enrollment (inclusion)]
- relationship between severity of neurological symptoms and cardiac injury [Time frame: enrollment (inclusion)]
- relationship between cardiovascular risk factors or preexisting cardio vascular abnormality and cardiac injury [Time frame: enrollment (inclusion)]
Eligibility criteria
Inclusion criteria
Patients treated for CO poisoning with HBOT in the hyperbaric and underwater medicine department of the Brest University hospital from 2015/01/01 to 2021/12/31
Exclusion criteria
- refusal
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHRU de Brest — Brest
Identifiers
NCT: NCT06549621 · COCARDIOTOX (29BRC22.0049)