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Not yet recruiting NCT06549322

Timing and Resistance Exercise: Impact on Eating and Metabolism

No phase Interventional Circadian Rhythm Energy Balance Appetitive Behavior Food Reward

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: The exercise in morning, The exercise in evening.
Who it may be relevant to
Registry conditions: Circadian Rhythm, Energy Balance, Appetitive Behavior, Food Reward. Basic parameters: 20 years — 30 years · Male.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Taiwan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

The Efficacy of Exercise Timing - Effects of Resistance Exercise on Eating Behavior and Energy Metabolism

Overview

Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field. Due to the better control of energy metabolism and physical activity levels in the morning, existing research on resistance exercise and eating behavior primarily focuses on experiments conducted in the morning, with only one study in the afternoon. No research has yet compared the potential differences between morning and evening resistance exercise. A one-year study aims to investigate the impact of morning and evening resistance exercise on physiological metabolism and eating behavior. Eighteen healthy male participants will be randomly assigned to a crossover design study, including AM exercise, PM exercise, and control (rest condition) trials. Variables including subjective appetite, appetite hormones (ghrelin, peptide YY), food preferences, ad libitum eating, dietary records, energy expenditure, and PBMCs circadian rhythm genes will be measured. This preliminary study through a multidimensional observation, the results will contribute to understanding the potential differences and mechanisms of morning and evening resistance exercise on physiological metabolism and eating behavior. In practical applications, conducting resistance exercise in the evening or at night aligns better with current lifestyles. The findings of this study can support the optimization of exercise benefits by validating the choice of exercise timing.

Interventions

  • Other The exercise in morning
    Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets. Exercise timing: AM 11:00-11:30
  • Other The exercise in evening
    Resistance exercises are in the following order: squat, bench press, deadlift. Each exercise consists of 3 sets with 7 repetitions, using a load of 70% 1RM with 60 sec of rest between sets. Exercise timing: PM 05:00-05:30

Primary outcome measures

  • Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite Subjective appetite [Time frame: 3 hours during each study intervention]
  • Change in acyl-Ghrelin [Time frame: 3 hours during each study intervention]
  • Change in PYY [Time frame: 3 hours during each study intervention]
  • Change in Leptin [Time frame: 3 hours during each study intervention]
  • Change in lactate [Time frame: 3 hours during each study intervention]
  • Change in PBMCs circadian rhythm genes [Time frame: 3 hours during each study intervention]
  • Energy intake [Time frame: The Before day, the durning day, and the day following the experiment.]
  • Energy expenditure [Time frame: The Before day, the durning day, and the day following the experiment.]
Secondary outcome measures (9)
  • Explicit liking [Time frame: 3 hours during each study intervention]
  • Explicit wanting [Time frame: 3 hours during each study intervention]
  • Implicit wanting [Time frame: 3 hours during each study intervention]
  • Relative preference [Time frame: 3 hours during each study intervention]
  • Taste appeal bias [Time frame: 3 hours during each study intervention]
  • Fat appeal bias [Time frame: 3 hours during each study intervention]
  • change in Cortisol [Time frame: 3 hours during each study intervention]
  • change in complete blood count [Time frame: 3 hours during each study intervention]
  • change in growth hormone [Time frame: 3 hours during each study intervention]

Eligibility criteria

Inclusion criteria

  • Age: 20-30
  • weight stable for at least 6 months

Exclusion criteria

  • Obesity (BMI > 30 kg/m² or body fat percentage > 25%)
  • Hypertension (blood pressure over 140/90 mmHg)
  • Heart disease
  • Cancer
  • Liver or kidney diseases
  • Any other conditions that could potentially influence the study's outcomes

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Treatment

Study locations

Taiwan · 1 center
  • National Taiwan Normal University — Taipei

Identifiers

NCT: NCT06549322 · 202401HM008

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗