Electroacupuncture Treatment of Behavioral and Psycological Symptoms in Patients With Alzheimer's Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Electroacupuncture treatment.
- Who it may be relevant to
- Registry conditions: BPSD (Behavioral and Psycological Symptoms of Dementia), Alzheimer's Dementia. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Registry of Electroacupuncture Treatment for Patients With Different Behavioral and Psycological Symptoms of Alzheimer's Disease
Overview
This study aims to establish a prospective case registration research platform for electroacupuncture in treating behavioral and psychological symptoms in patients with mild to moderate Alzheimer's disease, and to investigate the dose-effect relationship and cost-effectiveness of electroacupuncture for these symptoms.
Detailed description
To establish a prospective case registration research platform aimed at treating mild to moderate Alzheimer's disease patients presenting with behavioral and psychological symptoms. This platform will document the electroacupuncture treatment process, conduct regular assessments using neuropsychiatric questionnaires (NPI) and the Alzheimer's Disease Cooperative Study - Clinical Global Impression of Change Scale (ADAS-CGIC), and compare the effects of different parameters, treatment frequency, and duration of electroacupuncture on therapeutic outcomes for various behavioral and psychological symptoms in Alzheimer's disease patients. Furthermore, it aims to investigate the influencing factors of electroacupuncture treatment for behavioral and psychological symptoms.
Interventions
- Other Electroacupuncture treatment
Electroacupuncture treatment consists of conventional acupuncture and electrical stimulation. After acupuncture, the electrical stimulation is continuously stimulated.
Primary outcome measures
- Neuropsychiatric Inventory (NPI) [Time frame: NPI will be performed before treatment and every month after treatment for up to 24 months]
- Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) [Time frame: The ADCS-CGIC will be performed before treatment and every 2 month after treatment for up to 24 months]
Eligibility criteria
Inclusion criteria
- Meet the diagnostic criteria for AD in the NIA-AA standard;
- Clinical dementia rating scale ≤2 points;
- Accompanied by at least one psychobehavioral symptom, NPI：frequency × degree ≥1 point;
- Sign informed consent.
Exclusion criteria
1.There are contraindications for acupuncture treatment, such as the tendency of acupoint bleeding or allergy to metal
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 7 centers
- Beijing United Family Rehabilitation Hospital — Beijing
- China-Japan Friendship Hospital — Beijing
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences — Beijing
- Xuanwu Hospital of Capital Medical University — Beijing
- Beijing Geriatric Hospital — Beijing
- Fujian University of Traditional Chinese Medicine — Fuzhou
- The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine — Harbin
Identifiers
NCT: NCT06523309 · 2024-076-KY-01