Recruiting NCT06520982
Early Neurovascular Adaptations in Aging Women
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Norepinephrine, Isoproterenol, Acetylcholine, Nitroprusside.
- Who it may be relevant to
- Registry conditions: Women, Sympathetic Nervous System, Aging, Blood Flow. Basic parameters: 18 years — 70 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Interventions
- Drug Norepinephrine
Infused intra-arterially in a dose-response fashion - Drug Isoproterenol
Infused intra-arterially in a dose-response fashion - Drug Acetylcholine
Infused intra-arterially in a dose-response fashion - Drug Nitroprusside
Infused intra-arterially in a dose-response fashion - Drug Estrogen
Infused intra-arterially
Primary outcome measures
- Magnitude of forearm blood flow [Time frame: Change from baseline during infusion]
Eligibility criteria
Inclusion criteria
- Assigned female at birth (AFAB)
- 18-70 years of age
Exclusion criteria
- Assigned male at birth (AMAB)
- Pregnancy, breastfeeding
- Body mass index ≥30 kg/m2
- Taking medications known to affect metabolic, autonomic, and/or respiratory function
- Oral hormonal contraception in last 6 month
- History of hormone replacement therapy
- History of hyster- or oophor-ectomy
- Current smoking/Nicotine use
- Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- Chronic disease
- Blood pressure ≥140/90 mmHg
- Communication barriers
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Missouri-Columbia — Columbia
Identifiers
NCT: NCT06520982 · 2109189