Recruiting NCT06512935

Ventilator Pressure and Optimization of Compliance and Hemodynamics

No phase Interventional Bronchopulmonary Dysplasia Pulmonary Hypertension Due to Lung Diseases and Hypoxia Extreme Prematurity Ventilator Lung; Newborn

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied: The protocol lists: Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP.
Who it may be relevant to: Registry conditions: Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn. Basic parameters: 7 Days — 30 Days · All.
What needs checking: Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place: United States
Next step: Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Ventilator Pressure and Optimization of Compliance and Hemodynamics: VPOCH Trial

Overview

In preterm infants \< 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and improve oxygenation. This study may emphasize using point-of-care echocardiography along with electrical impedance tomography (EIT) to optimize ventilator settings in preterm infants. Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline to determine compliance, oxygenation, and cardiac hemodynamics at each step using echocardiography (ECHO) and EIT measurements. There will be a 15-minute washout period after changes prior to data collection.

Detailed description

Neonatal ventilation is a critical intervention to support breathing for newborns with respiratory distress syndrome (RDS), underdeveloped lungs, and evolving bronchopulmonary dysplasia (BPD). Positive airway pressure helps maintain patency of the airways and improves ventilation and oxygenation by maintaining the functional residual capacity (FRC) and keeping the alveoli patent. Peak inspiratory pressure (PIP) and positive end-expiratory pressure (PEEP) are terms commonly used in mechanical ventilation to describe the pressures applied to the respiratory system during the different phases of the breathing cycle. These parameters are essential in managing and optimizing ventilation for infants with respiratory failure.

This study will include preterm infants with recovering RDS born at age \< 34 weeks of gestational age on respiratory support via conventional mechanical ventilation or on high-frequency jet ventilation (HFJV). Infants will be randomized to the order of testing, increasing the PEEP (+1 cmH2O and +2 cmH2O) or decreasing the PEEP (+1 cmH2O and +2 cmH2O) with baseline measurements and Echo done at original PEEP and each subsequent PEEP.

Following informed consent, randomization will be performed using sequentially numbered sealed opaque envelopes. The randomization envelope will be signed before it is opened just before starting the study on each infant to indicate the first intervention for the infant.

This will be a single-center, randomized crossover study. The randomization envelope will be signed before it is opened just before starting the study on each infant to indicate the first intervention for the infant.

Randomization will occur after a baseline assessment of cardiac hemodynamics and respiratory status at the current set PEEP level. Infants will be randomized to the order of changes in PEEP levels during mechanical ventilation - increase followed by decrease versus decrease followed by increase. Randomization will use opaque sealed envelopes of varying block sizes from 2-4 with a 1:1:1:1 allocation ratio.

Infants will be randomized to a 4-hour crossover period of increasing and decreasing PEEP in random order from baseline and there will be a 15-minute washout period after changes before data collection.

All infants enrolled in the study will have routine monitoring, uniform target saturation ranges of 91-95% with alarm limits set at 88-95%, and standard care for the duration of the study. Pulse oximetry recordings will be downloaded using ixTrend (iexcellence, Wildau, Germany) software to a secure computer system for later data analysis.

Infants will continue standard treatment as recommended by the treating physician and will act as their own controls.

Primary secondary outcomes are described below. Electrical impedance tomography data will be collected in the Syntec machine and safely secured in the university computer system. Pulse oximetry recordings will be downloaded using ixTrend software to a secure computer system for later data analysis.

ECHO results will be stored in the unit ECHO machine and results will be reported by certified cardiologists blinded to the data collected to improve the study design's internal and external validity.

Interventions

Other Increase in the PEEP followed by decrease in the PEEP
Changes in the ventilator PEEP and its effect on lung and cardiac hemodynamics
Other Decrease in the PEEP followed by increase in the PEEP
Changes in the ventilator PEEP and its effect on lung and cardiac hemodynamics

Primary outcome measures

Change in cardiac index with increase/decrease in PEEP as measured by ECHO and EIT [Time frame: During a 4 hour cross-over period on either intervention]
PEEP of best compliance and best oxygenation as per EIT measurements [Time frame: During a 4 hour cross-over period on either intervention]

Secondary outcome measures (7)

Tidal volume variation [Time frame: During a 4 hour cross-over period on either intervention]
Oxygen saturation index [Time frame: During a 4 hour cross-over period on either intervention]
End-expiratory lung impedance (EELI), End-inspiratory lung impedance (EILI) [Time frame: During a 4 hour cross-over period on either intervention]
Transcutaneous carbon dioxide (TcCO2) values in response to varying PEEP levels [Time frame: During a 4 hour cross-over period on either intervention]
Respiratory Severity Score (RSS) [Time frame: During a 4 hour cross-over period on either intervention]
oxygen saturation (SpO2) values [Time frame: During a 4 hour cross-over period on either intervention]
% tidal distribution [Time frame: During a 4 hour cross-over period on either intervention]

Eligibility criteria

Inclusion criteria

Preterm infants with recovering respiratory distress syndrome (RDS) who were born at a gestational age < 34 weeks and are receiving respiratory support via conventional mechanical ventilation or on HFJV.

Post-natal age > 7 days and less than 1 month (outside golden week protocol)
Gestational age ≥ 21 weeks and ≤ 34 week
Infants with written informed consent obtained from legal guardian

Exclusion criteria

Blood culture-positive sepsis
Congenital anomalies affecting respiration
Cyanotic or ductal-dependent congenital heart disease
Newborns who are considered too unstable for study enrolment per neonatology attending
Newborns on pressors or steroids for maintaining cardiac output
Non-invasive ventilation or newborn with significant BPD (bronchopulmonary dysplasia) with pulmonary hypertension (HTN)
Open skin wounds or abrasions on the chest wall.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation: Randomized
Model: Crossover
Masking: Single blind
Primary purpose: Treatment

Study locations

United States · 1 center

Univerisity of Alabama — Birmingham

Identifiers

NCT: NCT06512935 · IRB-300013132

Primary sources (government registries)

ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗