Triage of Patients Presenting Beyond 24 Hours With Ischemic Stroke Due to Vertebrobasilar Artery Occlusion
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Endovascular Therapy.
- Who it may be relevant to
- Registry conditions: Stroke, Ischemic. Basic parameters: 18 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effectiveness and Safety of Endovascular Treatment vs. Best Medical Treatment in Patients With Vertebrobasilar Artery Occlusion Presenting Beyond 24 Hours of Last Known Well：a Prospective, Multicenter Registry Study
Overview
Endovascular thrombectomy (EVT) for posterior circulation occlusion is generally performed within a window of less than 24 hours from the time the patient was last known well (LKW). The efficacy and safety of EVT beyond the 24-hour window remain uncertain.
Interventions
- Other Endovascular Therapy
Endovascular therapy, as an adjunct to standard stroke therapy, may be beneficial for a very select population of patients who present with an acute ischemic stroke and have a proven large, proximal occlusion on imaging. Endovascular therapy includes any one or more of the following: Intra-arterial thrombolytic therapy, aspiration, stent retrieval, or a combination of multiple mechanical devices.
Primary outcome measures
- proportion of patients with Modified ranking scale (mRS) (0-3) at 90 days [Time frame: 90(±14)days]
Secondary outcome measures (3)
- distribution of patients with Modified ranking scale (mRS) (0-3) at 90 days [Time frame: 90(±14)days]
- Mortality within 90 days [Time frame: 90(±14)days]
- Incidence of symptomatic intracranial haemorrhage [Time frame: 90(±14)days]
Eligibility criteria
Inclusion criteria
- age≥18 years.;
- blockage in the vertebrobasilar artery, including the vertebral artery or basilar artery, determined using computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA)/digital subtraction angiography (DSA);
- VBAO occurrence more than 24 hours from LKW;
- none to mild premorbid disability defined by modified Rankin Scale (mRS) score ≤2;
- informed consent before enrollment in the clinical trials.
Exclusion criteria
- neuroimaging evidence of cerebral hemorrhage on presentation;
- lack of follow up information on outcomes at 90 days
- serious, advanced, or terminal illness.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Tianjin Huanhu Hospital — Tianjin
Identifiers
NCT: NCT06510634 · TJHH-2024-WM51