Sanger Human Cell Atlasing Project
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: sample collection.
- Who it may be relevant to
- Registry conditions: Human Development, Genetic Disease. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Sanger Human Cell Atlasing Project. Defining Human Cells in Terms of Gene Expression, Physiological States,Developmental Trajectories, and Location.
Overview
"Cell Atlasing" refers to a novel strategy to characterise cells in tissues at the molecular level in a quantitative manner. The international Human Cell Atlas consortium brings together a community of biologists, clinicians, technologists, physicists, computational scientists, software engineers, and mathematicians to capitalise on drawing together leaders with various biological, technical and computational expertise. The project is based on the aim to define all human cell types in terms of their distinctive patterns of gene expression, physiological states, developmental trajectories, and location. This will pave the way to create a reference map of all human cells as a basis for understanding human health and diagnosing, monitoring, and treating disease.
Detailed description
Previous methods for quantifying molecular states of cells included microarray and standard RNA-seq analysis on a tissue section (RNA-seq is a technique to look at the activity of all the genes in a cell). These methods estimate the activity of any given gene by averaging the signal from millions of cells. Given the heterogeneity of cell populations (i.e.how uniform they are), measurement of the mean values of signals overlooks the internal interactions and differences within a cell population that may be crucial for maintaining normal tissue function and facilitating disease progression.
The Sanger Human Cell Atlasing project will adopt various genomic approaches that will provide genome-wide information in a single experiment. This project aims to scale up the single cell genomics and high-throughput highly multiplex spatial gene expression profiling approaches. Coupled with powerful computational methods, this strategy will produce a comprehensive and systematic reference map of human cells, providing a fundamental blueprint of cell states for both basic biological research and clinical practice.
Interventions
- Other sample collection
New collected samples, as well as surplus surgical and diagnostic samples.
Primary outcome measures
- This project aims to scale up the single cell genomics and high-throughput highly multiplex spatial gene expression profiling approaches. [Time frame: 10 years]
Eligibility criteria
Inclusion criteria
- Samples are from the living and the deceased age 0 to 99+ from healthy and diseased individuals.
- All samples will have fully informed consent for use in research.
Exclusion criteria
- Samples taken without consent for use in future research
- Samples taken from individuals without the capacity to consent to use in research
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Other
Study locations
United Kingdom · 1 center
- Wellcome Sanger Institute — Cambridge
Identifiers
NCT: NCT06497673 · 260474