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Recruiting NCT06491823

Speech Motor Learning and Retention (Aim 2)

No phase Interventional Speech

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Adaptation, Adaptation baseline, Motor evoked potentials, Auditory evoked potentials.
Who it may be relevant to
Registry conditions: Speech. Basic parameters: 18 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Sensorimotor Basis of Speech Motor Learning and Retention

Overview

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.

Detailed description

The focus of this registration is Aim 2. Specific Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning. Plasticity is assessed using measures of cortical excitability. Specifically, auditory, somatosensory and motor evoked potentials are elicited using single pulse TMS (motor), pure tone bursts (auditory), and mentalis nerve stimulation (somatosensory). Tests of cortical excitability are interleaved with trials involving speech motor adaptation. Cortical excitability is also measured using these same measures 24 hours after learning to assess retention.

The Speech Motor Learning and Retention Master Protocol is NCT06467292.

Interventions

  • Behavioral Adaptation
    Auditory adaptation in speech
  • Behavioral Adaptation baseline
    Auditory baseline in speech
  • Device Motor evoked potentials
    motor evoked potentials will be obtained in each recording block
  • Device Auditory evoked potentials
    auditory evoked potentials will be obtained in each recording block
  • Device Somatosensory evoked potentials
    Somatosensry evoked potentials will be obtained in each recording block

Primary outcome measures

  • Speech motor learning [Time frame: Performance as measured at the end of learning (30 minute session)]
  • Retention of learning [Time frame: 24 hours after learning (re-test lasts 30 minutes)]
  • Motor evoked potentials (MEPs) [Time frame: Performance as measured at the end of learning (30 minute session)]
  • Somatosensory evoked potentials (SEPs) [Time frame: Performance as measured at the end of learning (30 minute session)]
  • Auditory evoked potentials (AEPs) [Time frame: Performance as measured at the end of learning (30 minute session)]

Eligibility criteria

Inclusion criteria

  • Fluent English speakers
  • Right-handed
  • Normal hearing
  • No speech disorder or reading disability

Exclusion criteria

  • Cardiac pacemaker
  • Aneurysm clip
  • Heart or Vascular clip
  • Prosthetic valve
  • Metal implants
  • Metal in brain, skull, or spinal cord
  • Implanted neurostimulator
  • Medication infusion device
  • Cochlear implant or tinnitus (ringing in ears)
  • Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
  • Psychoactive medications
  • Pregnancy

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Basic science

Study locations

United States · 1 center
  • Yale Child Study Center — New Haven

Identifiers

NCT: NCT06491823 · 2000037622_b · 1R01DC022097-01A1

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗